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About 50% of stroke patients develop persistent, multi-tract cognitive impairment, which can sometimes lead to dementia.
the risk of these injuries is relatively high, the long-term predictive factors for cognitive impairment are not yet clear.
rest state functional connection (rs-MRI) in MRI has attracted great interest for its ability to describe long-term brain changes and cognitive outcomes after ischemic stroke.
, however, most literature studies focus on a "critical window" of 3-6 months of increased neuroplasticity after stroke.
study found that at the group level, functional networks (post-stroke cognitive impairment (PSCI) networks) were able to identify people with cognitive impairment six months after stroke, regardless of cognitive field.
follow-up of stroke patients for more than six months may be used to predict cognitive decline and dementia at individual levels by developing machine learning algorithms.
machine learning algorithms can start with patient-level observations and look for a combination of features that can reliably predict results;
, Renaud Lopes of the University of Lille in France and others have looked at whether FUNCTIONAL Connectivity can predict long-term cognitive function 36 months after a mild stroke.
they included 72 first-time stroke participants in the baseline and followed them for 36 months.
then developed a ridge regression machine learning algorithm and predicted cognitive scores for the 36 months after stroke using a functional network of MRI measurements at six months, the Post-stroke Cognitive Impairment (PSCI) Network.
the accuracy of predictions in four cognitive areas (memory, attention/execution, language and visual spatial functions) and compared them with clinical data and other functional networks.
, the effects of cortular atrophy on cognition were assessed six months after stroke.
, the results are validated and their generality evaluated through a second independent data set , n-40.
results show that, based on the PSCI network, a machine learning model can predict memory, attention, visual spatial functions, and language functions (r-square: 0.67, 0.73, 0.55, and 0.48, respectively) 36 months after a stroke.
PSCI-based models are accurate for long-term cognitive function, at least as they are based on other functional networks or clinical data.
specific patterns in four cognitive areas have been shown to involve the upper left frontal cortical layer in memory, attention, and visual spatial function.
thickness six months after a stroke was not associated with cognitive function 36 months after stroke.
results are given from independent validation datasets.
significance of this study is the discovery of fmri functional connectivity, which can be based on machine learning models of PSCI networks to predict long-term cognitive outcomes after stroke.
long-term cognitive function can help identify patients at risk of dementia after stroke, benefiting from early cognitive rehabilitation and personalized treatment.
origins: Lopes, R., Bournonville, C., Kuchcinski, G., Dondaine, T., Mendyk, A.M., Viard, R., ... & Bordet, R. (2020). Prediction of Long-term Cognitive Functions after Minor Stroke, Using Functional Connectivity. Neurology.<!--5f39ae17-8c62-4a45-bc43-b32064c9388a: W3siYmxvY2tJZCI6IjEwNDEtMTYxMDg4MzkyNzU4NCIsImJsb2NrVHlwZSI6InBhcmFncmFwaCIsInN0eWxlcyI6eyJhbGlnbiI6ImxlZnQiLCJpbmRlbnQiOjAsInRleHQtaW5kZW50IjowLCJsaW5lLWhlaWdodCI6MS43NSwiYmFjay1jb2xvciI6IiIsInBhZGRpbmciOiIifSwidHlwZSI6InBhcmFncmFwaCIsInJpY2hUZXh0Ijp7ImRhdGEiOltdLCJpc1JpY2hUZXh0Ijp0cnVlLCJrZWVwTGluZUJyZWFrIjp0cnVlfX0seyJibG9ja0lkIjoiMjQ0Ni0xNjEwODg1ODk4MTIyIiwiYmxvY2tUeXBlIjoicGFyYWdyYXBoIiwic3R5bGVzIjp7ImFsaWduI joibGVmdCIsImluZGVudCI6MCwidGV4dC1pbmRlbnQiOjAsImxpbmUtaGVpZ2h0IjoxLjc1LCJiYWNrLWNvbG9yIjoiIiwicGFkZGluZyI6IiJ9LCJ0eXBlIjoicGFyYWdyYXBoIiwicmljaFRleHQiOnsiZGF0YSI6W3siY2hhciI6Ik4iLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoiZSIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiJ1Iiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6InIiLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0sey JjaGFyIjoibyIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiJsIiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6Im8iLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoiZyIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiJ5Iiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6Ii0iLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoiZiIsInN0eWxlcyI6eyJiYWNrLWNvbG9 yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiJNIiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6IlIiLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoiSSIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiLlip8iLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoi6IO9Iiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6Iui /niIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiLmjqUiLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoi5oCnIiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6Iu+ 8jCIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiLlj68iLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoi6aKEIiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6Iua1iyIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiLohJEiLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoi5Y2SIiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6IuS4rSIsInN0eWxlcyI6eyJiYWNr LWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiLlkI4iLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoi55qEIiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6IumVvyIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiLmnJ8iLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoi6K6kIiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6IuefpSIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9f Sx7ImNoYXIiOiLnu5MiLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoi5p6cIiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19XSwiaXNSaWNoVGV4dCI6dHJ1ZSwia2VlcExpbmVCcmVhayI6dHJ1ZX19LHsiYmxvY2tJZCI6IjgzMTgtMTYxMDg4NTg5ODYyNSIsImJsb2NrVHlwZSI6InBhcmFncmFwaCIsInN0eWxlcyI6eyJhbGlnbiI6ImxlZnQiLCJpbmRlbnQiOjAsInRleHQtaW5kZW50IjowLCJsaW5lLWhlaWdodCI6MS43NSwiYmFjay1jb2xvciI6IiIsInBhZGRpbmciOiIifSwidHlwZSI6InBhcmFncm FwaCIsInJpY2hUZXh0Ijp7ImRhdGEiOlt7ImNoYXIiOiLCoCIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fV0sImlzUmljaFRleHQiOnRydWUsImtlZXBMaW5lQnJlYWsiOnRydWV9fSx7ImJsb2NrSWQiOiI5Mjk1LTE2MTA4ODU4OTcxMjMiLCJibG9ja1R5cGUiOiJwYXJhZ3JhcGgiLCJzdHlsZXMiOnsiYWxpZ24iOiJsZWZ0IiwiaW5kZW50IjowLCJ0ZXh0LWluZGVudCI6MCwibGluZS1oZWlnaHQiOjEuNzUsImJhY2stY29sb3IiOiIiLCJwYWRkaW5nIjoiIn0sInR5cGUiOiJwYXJhZ3JhcGgiLCJyaWNoVGV4dCI6eyJkYXRhIjpbeyJ jaGFyIjoi5aSnIn0seyJjaGFyIjoi57qmIn0seyJjaGFyIjoiNSJ9LHsiY2hhciI6IjAifSx7ImNoYXIiOiI
