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    Home > Active Ingredient News > Study of Nervous System > Neurology: How are different drug classes associated with periodic limb movements (PLMs)?

    Neurology: How are different drug classes associated with periodic limb movements (PLMs)?

    • Last Update: 2022-04-22
    • Source: Internet
    • Author: User
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    Periodic limb movements (PLMs) duringsleep are repetitive limb movements that primarily involve the legs but can also occur in the upper extremities
    .


    The reasons for PLMs have not been fully elucidated


    Periodic Limb Movements (PLMs) Diabetic Vascular

    Here, we sought to explore the association of broad drug classes with PLM frequency, while controlling for the effects of known risk factors for PLM in a large patient cohort
    .

    Here, we sought to explore the association of broad drug classes with PLM frequency, while controlling for the effects of known risk factors for PLM in a large patient cohort
    .


    Single, diagnostic , overnight laboratory polysomnographywas performed on 3488 consecutive patients presenting between 2010-2015 to determine PLMI
    .


    Medication status and medical comorbidities were collected through patient questionnaires


    diagnosis

    • The median age of the cohort was 56.
      0 years (48.
      2%)
      .
    • After adjustment for age, sex, body mass index, relevant comorbidities, and sleep parameters, the use of selective serotonin reuptake inhibitors (SSRIs) (OR=1.
      52) and serotonin-norepinephrine reuptake inhibitors ( SNRI) (OR=1.
      99) was associated with increased PLMI
      .


      Conversely, gabapentins (OR=0.


      Use of SSRIs and SNRIs was associated with increased PLMI, whereas use of gabapentin, stimulants, benzodiazepines, and dopamine agonists was associated with decreased PLMI


      Source: Hoxha O, Jairam T, Kendzerska T, et al.


      Hoxha O, Jairam T, Kendzerska T, et al.
      Association of Periodic Limb Movements with Medication Classes: A Retrospective Cohort Study [published online ahead of print, 2022 Feb 7].
      Neurology.
      2022;10.
      1212/WNL.
      0000000000200012.
      doi:10.
      1212 /WNL.
      0000000000200012Leave a message here
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