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immunity
Childhood- onset multiple sclerosis , although relatively rare (affecting ≤5% of MS patients), represents a unique opportunity to examine exposures, such as the gut microbiome, very close to the actual biological onset of MS
Currently, the functional potential of the MS microbiome is unclear, in part due to a lack of studies utilizing metagenomic sequences
Little is known about the functional potential of the gut microbiome in pediatric multiple sclerosis, and researchers used fecal samples from pediatric-onset MS patients and normal controls for metagenomic analysis
antibiotic
- The mean age at onset of MS was 13.
The functional potential and taxonomy of the gut microbiota differed between pediatric-onset MS and controls, including a high prevalence of the archaeal methanogenesis pathway and the absence of the lactic acid fermentation pathway
Mirza AI, Zhu F, Knox N, et al.
Metagenomic Analysis of the Pediatric-Onset Multiple Sclerosis Gut Microbiome [published online ahead of print, 2021 Dec 22].
Neurology.
2021;10.
1212/WNL.
0000000000013245.
doi:10.
1212/WNL .
0000000000013245
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