Neurology: Nasopharyngeal cancer survivors have an increased overall risk of stroke, especially in stage 1

In 2018 , there were more than 129,000 new cases of nasopharyngeal carcinoma (NPC) worldwide and more than 72,000 deaths
.

Although the addition of chemotherapy in recent decades has helped improve efficacy, radiotherapy is still the cornerstone of treatment

In 2018 , there were more than 129,000 new cases of nasopharyngeal carcinoma (NPC) worldwide and more than 72,000 deaths

The epidemiology and treatment of nasopharyngeal carcinoma are different from other head and neck cancers

Carotid artery stenosis caused by radiation leads to a cerebrovascular event or stroke.

2005 Nian 1 January to 31 December 2017, the researchers conducted a cohort study confirmed a population-based patients with nasopharyngeal carcinoma
.

Taking the Cancer and Stroke Disease Registry and the Singapore general population as the reference population, the age-standardized incidence difference (SIRDs) ratios (SIRs) of all causes of death within 30 days after stroke of nasopharyngeal cancer survivors are reported, as well as the cumulative incidence of stroke and all causes of death.

2005 Nian 1 January to 31 December 2017, the researchers conducted a cohort study confirmed a population-based patients with nasopharyngeal carcinoma

• When the median follow-up time of 3849 patients diagnosed with nasopharyngeal carcinoma was 48.
  4 months (IQR19.
  8-92.
  9), 96 patients had a stroke
  .
  
• The overall SIRD of stroke was 3.
  12 (95% CI 2.
  09-4.
  15), and the SIR was 2.
  54 (95% CI 2.
  08-3.
  10)
  .
  
  SIRD was the highest in the 70-79-year-old age group (8.
  
  Compared with the general population, the overall risk of stroke for nasopharyngeal cancer survivors is significantly increased, especially in stage 1 disease
  
   This study provides secondary evidence that nasopharyngeal cancer survivors have an increased risk of stroke compared with the general population
  
  Literature source: https://n.
  aan.
  80599.
  net/content/early/2021/11/12/WNL.
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