Neurology: People who exercise regularly have better cognitive ability!

Although the ε4 allele of the apolipoprotein E (APOE) gene is the main genetic risk factor for Alzheimer’s disease (AD), more and more evidence shows that this allele is recognized in Parkinson’s disease (PD).
There is also a potential role in cognitive barriers.

APOE ε4 alleles mainly affect cognitive ability through amyloid-related pathways.
However, recent studies have found that APOE ε4 alleles can exacerbate α-synuclein lesions in the brain, thereby enabling people to gain insight into the link mechanism between APOE genotype and neurodegeneration of Parkinson's disease.

As we all know, physical activity has a beneficial effect on PD.
Some studies have shown that PD patients who exercise regularly show better clinical outcomes and improved quality of life.
Although the mechanism of physical activity on Parkinson's disease is not very clear, it may include neuroprotection of substantia nigra neurons and their connections, and increased dopaminergic neurotransmission as the expression of D2 dopamine receptors increases.

Previous data showed that physical activity can change the impact of APOE ε4 on the development and progress of AD.

Therefore, it can be hypothesized that physical activity also plays a role in regulating the association between APOE ε4 and cognition in PD.
However, there are currently no studies reporting this interaction in PD patients.

Physical activity also plays a role in regulating the association between APOE ε4 and cognition in PD.
However, there are currently no studies reporting this interaction in PD patients.
Physical activity also plays a role in regulating the association between APOE ε4 and cognition in PD.
However, there are currently no studies reporting this interaction in PD patients.

Therefore, Ryul Kim and others of Inha University in South Korea explored whether physical activity can attenuate the negative impact of APOE ε4 on the longitudinal cognitive decline of patients with early PD.

In addition, it was further studied whether this benefit of physical activity was related to changes in striatal dopaminergic activity.

However , there is a clear interaction between physical activity and APOE ε4, that is, higher physical activity is associated with slower APOE ε4 related cognitive decline.

, There is a significant interaction between physical activity and APOE ε4, that is, higher physical activity is associated with slower APOE ε4 related cognitive decline.
, There is a significant interaction between physical activity and APOE ε4, that is, higher physical activity is associated with slower APOE ε4 related cognitive decline.

Regarding the changes in the DAT activity of the striatum, no obvious interaction was found between physical activity and the APOE ε4 allele.

The important significance of this study is that it is found that the increase in physical activity reduces the vulnerability of early cognitive decline in PD patients associated with APOE ε4.
This protective effect does not appear to be mediated by the dopaminergic function of the striatum.

Original source: neurology.

org/content/early/2021/03/31/WNL.
0000000000011852" target="_blank" rel="noopener">Association of Physical Activity and _APOE_ Genotype With Longitudinal Cognitive Change in Early PD

neurology.
org/content/early/2021/03/31/WNL.
0000000000011852" target="_blank" rel="noopener">_APOE_ and the Activity of the Physical Association or with Genotype With Early Longitudinal Cognitive Change in the PD
neurology.
org/content/early/2021/03/31/WNL.
0000000000011852" target="_blank" rel="noopener">Ryul Kim, Sangmin Park, Dallah Yoo, Jin-On Jun the Sun, Beomseok Jeon
neurology.
org/content/early/2021/03/31/WNL.
0000000000011852" target="_blank" rel="noopener">.
Neurology-Mar 2021, 10.
1212 / WNL.
0000000000011852; the DOI: 10.
1212 / WNL.
0000000000011852 in this message