Neurology |。 Risk factors for sleep disorders are similar to, but different, to Parkinson's disease

ReM sleep behavior disorder (REM sleep behavior disorder, RBD) is characterized by easy dreaming, and this dream behavior is closely related to the loss of normal muscle relaxation function, which can be seen in the polysymonic sleep map (PSG).
Previous longitudinal studies have shown an increased risk of neurodegenerative diseases in patients with idlympose RBD (iRBD), mainly α-synhaptic nucleoprotein diseases, including Parkinson's disease (PD), Louis' body type dementia (DLB) and multisyscular atrophy.
more than 80% of iRBD patients will develop these neurodegenerative diseases in a decade or more.
Given the close relationship between iRBD and neurodegenerative diseases mediated by synactin, it is important to study the risk factors for iRBD to reveal the causes and pathogenesis of α-synactal nucleoprotein disease and to develop prevention strategies.
recent years, a number of large-scale population-based studies have explored the risk factors for RBD.
most of these studies use questionnaires as a screening tool for diagnosing RBD because PSG is time-consuming, expensive, and unworkable.
these studies report that RBD not only has common risk factors for Parkinson's disease and dementia, such as head injuries, low levels of education, but also unique risk factors, including smoking and drinking.
, however, previous studies have failed to delve into other important factors, such as carbon monoxide (CO) poisoning, a family history of Parkinson's disease or dementia, and other pre-symptoms of Parkinson's disease.
team at Xuanwu Hospital, Capital Medical University, based on Bejing Longitudinal Study on Aging II (BLSA II) cohort, analyzed 7,225 participants without Parkinson's disease and dementia.
evaluate potential RBD (Possible RBD, pRBD) patients through the RBD scale (RBD-Hong Kong).
found that 219 people (3.0%) were thought to have pRBD.
pRBD participants had more non-motor and motor symptoms of Parkinson's disease (PD).
with pRBD were more likely to have a family history of Parkinson's disease or dementia.
pRBD was significantly associated with hyperlipidemia, smoking, carbon monoxide poisoning, and exposure to non-occupational pesticides.
The main clinical significance of this study, based on the Beijing Aging Queue, is that, on the one hand, the relationship between previously reported pRBD and hyperlipidemia, smoking, pesticide exposure, and a variety of PD pre-symptoms is further validated.
, on the other hand, they found that a family history of Parkinson's disease/dementia and carbon monoxide poisoning were risk factors for pRBD.
risk factors for pRBD are similar to PD, but they are different.
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