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Defining and understanding Alzheimer's disease from a biological point of view provides a prerequisite for understanding the various clinical syndromes associated with AD pathology.
, the view of AD is no longer to treat it as a traditional forgotten clinical syndrome.
by an autopsy suggests that local cortical syndromes, such as post-cortical atrophy and logogenic progressive aphasia, may be caused by AD pathology.
molecular imaging studies in recent years have expanded this concept because they have shown that the pathological distribution of au protein is more closely related to clinical manifestations than amyloid-β.
in cognitive tests, AD's behavior/execution dysfunction is mainly manifested in behavioral inhibition, apathy, stereotyped behavior, or executive dysfunction.
behavioral/executing dysfunctional AD can be attributed to pathophysiology of AD, while clinical symptoms of frontal temporal lobe dementia overlap with behavioral/execution dysfunction AD, identification diagnosis remains a challenge.
(n ≤6) of the distribution of A-beta and Tau in AD for the assessment of behavioral/execution disorders (AD) and the results are contradictory.
Subsequent larger studies did not find substantial preleteual atrophy, resulting in "behavioral/execution disorder AD" exceeding "preletain variation AD", however, these larger studies did not assess the distribution of A-beta or Tau proteins, which may be associated with clinical manifestations and can predict local neurodegenerative lesions.
Joseph Therriault of McGill University and others explored the relationship between A-PET, tau-PET, atrophy and Alzheimer's behavior/execution disorder performance (AD), the differences between these and oblivional AD, and their relationship to clinical symptoms.
them, they compared 25 forgotten AD patients with 131 cognitively impairment elderly people.
all participants assessed A beta and tau with PET, and collected data using MRI and psychological scales.
they found that the pre-cortique Tau aggregation pattern of behavioral/execution disorder-type ADs was concentrated in the inner frontal frontal leaf, front buckle back, and pre-leaf cerebral cortique peaks compared to forgotten AD.
A-beta distribution and atrophy between the two ADs, there was no significant difference.
ROC curve showed that Tau-PET intake of the inner frontal frontal leaf, front buckle back, and frontal leaf corties was good for regional behavior/execution disorders and forgetful AD.
and the forekin Tau load is associated with the degree of dysfunction in execution.
importance of this study is that for patients with behavioral/execution disorderS, the preleuital Tau lesions provide good evidence for clinically identifiable diagnosis of AD.
Therriault, J., Pascoal, T. A., Savard, M., Benedet, A. L., Chamoun, M., Tissot, C., ... & Rej, S. (2020). Topographical distribution of amyloid-β, tau and atrophy in behavioral/dysexecutive AD patients. Neurology.<!--5f39ae17-8c62-4a45-bc43-b32064c9388a: W3siYmxvY2tJZCI6IjIwMjEtMTYwOTQ1MzIyOTkyNyIsImJsb2NrVHlwZSI6InBhcmFncmFwaCIsInN0eWxlcyI6eyJhbGlnbiI6ImxlZnQiLCJpbmRlbnQiOjAsInRleHQtaW5kZW50IjowLCJsaW5lLWhlaWdodCI6MS43NSwiYmFjay1jb2xvciI6IiIsInBhZGRpbmciOiIifSwidHlwZSI6InBhcmFncmFwaCIsInJpY2hUZXh0Ijp7ImRhdGEiOlt7ImNoYXIiOiLku44iLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6IueUnyIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoi54mpIiwic3R5bGVzIjp7ImZvbnQtc2l6Z SI6MTZ9fSx7ImNoYXIiOiLlraYiLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6IueahCIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoi6KeSIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTZ9fSx7ImNoYXIiOiLluqYiLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6IuWOuyIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoi5a6aIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTZ9fSx7ImNoYXIiOiLkuYkiLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6IuWSjCIsInN0eW xlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoi55CGIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTZ9fSx7ImNoYXIiOiLop6MiLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6IumYvyIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoi5YW5Iiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTZ9fSx7ImNoYXIiOiLmtbciLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6Ium7mCIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoi55eFIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTZ9fSx7ImN oYXIiOiLvvIwiLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6IuS4uiIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoi6K6kIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTZ9fSx7ImNoYXIiOiLor4YiLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6IuS4jiIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoiICIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoiQSIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoiRCIsInN0eWxlcyI6eyJmb250LXNpemUi OjE2fX0seyJjaGFyIjoiICIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoi55eFIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTZ9fSx7ImNoYXIiOiLnkIYiLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6IuebuCIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoi5YWzIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTZ9fSx7ImNoYXIiOiLnmoQiLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6IuWQhCIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoi56eNIiwic3R5bGVzI jp7ImZvbnQtc2l6ZSI6MTZ9fSx7ImNoYXIiOiLkuLQiLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6IuW6iiIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoi57u8Iiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTZ9fSx7ImNoYXIiOiLlkIgiLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6IuW+gSIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoi5o+ QIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTZ9fSx7ImNoYXIiOiLkvpsiLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6IuS6hiIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoi5YmNIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTZ9fSx7ImNoYXIiOiLmj5AiLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6IuOAgiIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoi6L+ ZIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTZ9fSx7ImNoYXIiOiLmoLciLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6Iu+ 8jCIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoi55yLIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTZ9fSx7ImNoYXIiOiLlvoUiLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6IkEiLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6IkQiLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6IiAiLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6IueahCIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoi6KeGIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTZ9fSx7 ImNoYXIiOiLop5IiLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6Iu+ 8jCIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoi5LiNIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTZ9fSx7ImNoYXIiOiLlho0iLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6IuaYryIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoi5oqKIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTZ9fSx7ImNoYXIiOiLlroMiL
