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TAR-DNA binding protein 43 kDa (TDP-43) protein disease exists in up to 50% of the elderly brain, and has a strong correlation with cognitive impairment.
TAR-DNA binding protein 43 kDa (TDP-43) protein disease exists in up to 50% of the elderly brain, and has a strong correlation with cognitive impairment.
Cross-sectional data indicate that TDP-43 protein lesions occur in a stereotyped, hierarchical spatiotemporal pattern in the brain.
TDP-43 deposits first appear in the amygdala and then in the hippocampus.
The accumulation of TDP-43 is a pathological feature shared by several age-related neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
In order to test the hypothesis that there is an inverse association between senile diabetes (DM) patients and hemoglobin A1C (HbA1c) and TDP-43 levels, experts from the Department of Neuropsychology at the University of Chicago conducted related research.
The study used clinical pathology from 3 communities to study the deceased's data before and after death.
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The average age of death of the participants (n = 817) was 90 years old, 3/4 were women, and 1/4 had DM.
A higher HbA1C level is associated with a lower TDP-43 score (estimated value -0.
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The researchers pointed out that at the pathological level, the development of cognitive and behavioral abnormalities is related to the accumulation of hyperphosphorylated TDP-43 protein in the motor outer cortex .
On the pathological level, the development of cognitive and behavioral abnormalities is related to the hyperphosphorylation of TDP-43 in the motor outer cortex.
In general, in the elderly, high levels of HbA1C are related to lower TDP-43 protein load, and the relationship between DM and TDP-43 needs further study.
references:
Association of Hemoglobin A1C With TDP-43 Pathology in Community-Based Elders.
Association of Hemoglobin A1C With TDP-43 Pathology in Community-Based Elders.
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