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    Home > Active Ingredient News > Study of Nervous System > ​Neurology: "Ticagrelor + Aspirin" in the treatment of ischemic stroke, the benefits outweigh the disadvantages?

    ​Neurology: "Ticagrelor + Aspirin" in the treatment of ischemic stroke, the benefits outweigh the disadvantages?

    • Last Update: 2022-06-10
    • Source: Internet
    • Author: User
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    *For medical professionals to read and reference clinical information only, 1s touches a new study published in Neurology.
    The THALES trial investigated ticagrelor combined with aspirin in the treatment of acute mild to moderate ischemic stroke or Short-term benefits and risks of transient ischemic attack (TIA)
    .

    How this study was done The study included 11,016 patients (5,523 in the ticagrelor plus aspirin group and 5,493 in the aspirin group), with a mean age of 65 years, of whom 39% were women
    .

    The cumulative incidence of irreversible efficacy and safety outcomes at different time points during the 30-day treatment period was assessed
    .

    Efficacy outcome (major ischemic event) was defined as a composite event of ischemic stroke or non-hemorrhagic death, safety outcome (major bleeding) was defined as a composite event of intracranial hemorrhage and fatal bleeding, and "net" clinical effect was defined for the combination of these two endpoints
    .

    RESULTS: Ticagrelor reduced major ischemic events in the first week (4.
    1% vs 5.
    3%; absolute risk reduction 1.
    15%, 95% CI, 0.
    36%-1.
    94%) and remained lower throughout the 30-day treatment period; Major bleeding increased during the first week and remained relatively stable in subsequent weeks (absolute risk increase of approximately 0.
    3%)
    .

    Cumulative analysis showed that the "net" clinical effect of ticagrelor plus aspirin was beneficial (absolute risk reduction 0.
    97%, 95% CI, 0.
    17%-1.
    77%) at the first week and remained unchanged over 30 days
    .

    The above results show that in patients with mild to moderate ischemic stroke or high-risk TIA, the therapeutic effect of ticagrelor combined with aspirin is reflected from the first week
    .

    The ischemic benefit of ticagrelor plus aspirin outweighed the risk of major bleeding throughout the treatment period, a finding that may support a 30-day regimen of ticagrelor plus aspirin in these patients
    .

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    Use the clinical medication Find the "Top Issues Essentials" follow column and subscribe to the column, and read a new top issue every day! Download the Doctor Station App and subscribe anytime, anywhere~ References: [1] Wang Y, Pan Y, Li H, Amarenco P, Denison H, Evans SR, Himmelmann A, James S, Knutsson M, Ladenvall P, Molina CA, Johnston SC.
    Time Course for Benefit and Risk of Ticagrelor and Aspirin in Acute Ischemic Stroke or Transient Ischemic Attack.
    Neurology.
    2022 Apr 18:10.
    1212/WNL.
    0000000000200355.
    doi:10.
    1212/WNL.
    0000000000200355.
    Epub.
    ahead of print.
    PMID:35437261
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