Neurology: Tracking for 13 years (age 1 month - 13 years old), the trend of T1-W/T2-W ratio is related to multi-dimensional intelligent development, and the increase of perinatal risk factors deviates from normal development risk

(2) Determine whether perinatal variables, including moderate and severe brain abnormalities, small gestational age, infection, and bronchopulmonary dysplasia, correlate with (A) cross-sectional or (B) longitudinal T1-w/T2-w in children with VP value related

(3) Determine whether (A) cross-sectional or (B) longitudinal changes in T1-w/T2-w values ​​are associated with intelligence, motor, working memory, attention, language, executive function, memory and learning, Academic and behavioral functioning are related, and whether the relationship differs between birth groups

• Of the 224 VP participants and 76 FT participants, 197 VP and 55 FT participants had available T1-w/T2-w data for at least one time point
  
  VP birth and multiple known perinatal risk factors are associated with long-term reductions in T1-w/T2-w ratios in white matter areas in childhood and adolescence, which may be related to changes in microstructure and myelin content
  
  Thompson D, Yuan-Mou Yang J, Chen J, et al.
  Brain White Matter Development Over the First 13 Years in Very Preterm and Typically Developing Children Based on the T1-W/T2-W Ratio [published online ahead of print, 2021 Dec 22].
  Neurology.
  2021; 10.
  1212/WNL.
  0000000000013250.
  doi: 10.
  1212/WNL.
  0000000000013250
  
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