Neurology: When stroke patients want to get a good prognostic, the start time of in-vascular therapy is important

A recent study published in Neurology, an authoritative journal in the field of neurology, aims to explore the relationship between intravascular therapy (EVT) start time and mid-functional prognosis in patients with acute ischemic stroke (EVS).
retrospective queue study included all AIS cases treated with EVT from two stroke centre registries between January 2012 and December 2018.
the study's main outcomes were a 90-day improved Rankin scale (mRS) and a utility-weighted mRS (uw-mRS) score.
scale ratio model is used to calculate the ratio ratio to measure the likelihood that intervention at a given EVT start time will result in a lower MS score.
158 patients were assigned an average of 12 time periods to start EVT.
the main results of the study support the best time to start EVT is 08:00-10:20 and 10:20-11:34 (or 0.53, respectively); 95% confidence interval (CI) is 0.38 to 0.75; P.lt;0.001; OR is 0.62; 95% CI is 0.44 to 0.87; P is 0.006), but ineffective EVT starts at 15:55-17:1 5 and 18:55-20:55 (OR is 1.47; 95% CI is 1.03 to 2.09; P is 0.034; OR is 1.49; 95% CI is 1.03 to 2.15; P is 0.033).
between 10:20 and 11:34, symptoms start significantly longer until EVT, while t-PA venous thrombosis is significantly lower (P.lt;0.004 and P.012, respectively).
, for patients with AIS, starting EVT in the morning can improve mid-stage function, while EVT during off-hours can reduce the patient's mid-functional prognostication.