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Current guidelines recommend that patients with acute ischemic stroke within 4.
5 hours of onset should be given intravenous alteplase thrombolytic therapy
.
However, when these criteria are followed, a significant proportion of stroke patients whose onset time is unknown (accounting for 25% of all patients) are excluded
Recently, we have developed a CT-based quantitative method of water uptake in lesions, which can accurately identify patients within a 4.
5-hour time window of onset
.
The purpose of this study is to develop a visual grading method based on the intake of diseased water on hospitalized CT to identify patients within 4.
In November 2021, Jens Minnerup and others from Germany announced their research results on Neurology, with the purpose of verifying the hypothesis: CT hypoperfusion-low density mismatches identify patients with ischemic stroke within 4.
5 hours of onset
.
Figure 1.
An example of a lack of hypoperfusion-low density mismatch in patients with onset> 4.
5h
.
(A) A small piece of cortical acute ischemic core lesions (ie, brain tissue with a high probability of infarction) can be easily identified in CBV and CBF, and obvious low density (ie, clear brain tissue) can be seen on plain brain CT (NCCT) Visible infarction)
Figure 2.
An example of hypoperfusion-low density mismatch in patients with an onset of <4.
5h
.
(A) Acute ischemic core lesions (ie, tissues with high infarction probability) can be easily identified on CBF, no lesions are seen on CBV, and there is no obvious low density on plain CT (ie no clear infarction)
This study is a retrospective multi-center study, using CT hypoperfusion-low density mismatch to identify stroke patients within 4.
5 hours of onset
.
The study subjects are patients with acute ischemic stroke and the time of onset is known
Among 666 patients, 548 cases (82.
3%) underwent multimodal CT examination within 4.
5 hours of onset, and 118 cases (17.
7%) underwent multimodal CT examination 4.
5 hours after onset
.
Among the patients within 4.
Original source:
Original source:Peter B.
CT Hypoperfusion-Hypodensity Mismatch to Identify Patients With Acute Ischemic Stroke Within 4.
5 Hours of Symptom Onset in this message
