Neuromodulation: Stimulation of the dorsal root ganglion on the spinal cord ascending effect in patients with chronic pain

The dorsal root ganglion (DRG) is a component of the peripheral nervous system (PNS), located in various segments outside the spinal cord
.

It contains the pseudo-unipolar spinal nerve cell body of the primary sensory afferent of each spinal nerve

Many pain relief mechanisms during DRG have been hypothesized, including 1) suppression of abnormal neuronal pulses propagating at the DRG t-junction, 2) anti-inflammatory effects and changes in DRG gene expression, 3) autonomic changes through sympathetic nerve synapses , 4) The influence on the upper nerve axis of the spinal cord
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Functional magnetic resonance imaging (fMRI) was used to study the possibility of the effects on the spinal cord of rodents, indicating that DRG modulates the cortex and subcortical structures

This article assumes that the neuromodulation of this key structure in PNS, the dorsal root ganglia, can regulate the power spectrum of theta, alpha and low beta bands at rest as a potential analgesic biomarker

The histogram depicts the results of no pain (n=2), mild pain (n=4), moderate pain (n=4) and severe pain group (n=3) under DRGS-OFF conditions

Sixteen patients were included in this study
.

The preoperative baseline pain score was calculated based on the average of the morning and afternoon pain scores in the pain diary of each patient during the week before DRGS implantation

Displays significant changes in the power spectrum activity of a representative patient detected by the magnetometer

After turning off DRGS, the cortex θ of patients with severe pain increased significantly.
Compared with patients who reported less pain, the cerebral cortex α (7–13 Hz) power of patients was reduced
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In the process of DRGS-mediated pain relief, this power shift to low frequencies is in contrast to the shift to high frequency power spectrum (low β13-20hz activity)

The results of the study provide support for the search for potential pain biomarkers for application
.

The results of the study provide support for the search for potential pain biomarkers for application
.

Parker, T.

Parker, T.
, Huang, Y.
, Raghu, ALB, FitzGerald, J.
, Aziz, TZ and Green, AL (2021), Supraspinal Effects of Dorsal Root Ganglion Stimulation in Chronic Pain Patients .
Neuromodulation: Technology at the Neural Interface Aziz , TZ and Green, AL (2021 ), supraspinal Effects of Dorsal Root Ganglion Stimulation in Chronic Pain Patients in this message