Neuromodulation: Transcranial AC stimulation can reduce neural network synchronization and persistent dizziness

Oscillatory stimulation is a rich natural and man-made source in the environment

The entorhinal cortex is considered to be an important matrix for the maintenance of persistent MdDS because it can be entered through periodic stimulation, is functionally connected to the large neocortex, and plays a key role in updating the hippocampus and navigation-related environmental characteristics

Stimulus waveform and electric field distribution

To determine the relationship between ASSR and MdDS symptom status, a group of MdDS patients was compared with an age-matched healthy control group, and the relationship between ASSR changes and transcranial alternating current stimulation (tACS) changes in the perception of oscillatory vertigo was determined

Patients with refractory MdDS lasting at least 6 months receive a single frontal-parietal-occipital tACS treatment for 6 months, using "n/1" double-blind random design: alpha frequency in phase, alpha frequency inverted, and γ frequency inverted Contrast contrast

ASSR and treatment response of MdDS participants and healthy controls

Twenty-four MdDS patients participated in the study (mean age 53.

In short, this is the first study of how tACS can improve clinical symptoms by reducing pathological oscillations in the brain network