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    Home > Biochemistry News > Biotechnology News > "Neuron" first discovered autism cerebrospinal fluid protein markers

    "Neuron" first discovered autism cerebrospinal fluid protein markers

    • Last Update: 2021-12-26
    • Source: Internet
    • Author: User
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    • The sedative brain protein is very low in autistic patients, causing epilepsy

    • Because of genetic mutations, the brain has not stopped being overactive

    • 30-50% of children with autism also suffer from epilepsy

    Why do so many children with autism often suffer from epilepsy? Scientists from Northwestern Medical Corporation have discovered an important brain protein that can quiet overactive brain cells.


    This protein can be detected in the cerebrospinal fluid, making it a promising marker for diagnosing autism and treating epilepsy that accompanies autism


    Scientists know that once this gene is mutated, it can lead to autism and epilepsy


    This protein called CNTNAP2 is appropriately called "catnap2" and is produced when brain cells are overactive


    In this study, Penzes and his colleagues analyzed the cerebrospinal fluid in autism and epilepsy patients and mouse models


    The research will be published in the December 17th issue of Neuron


    New discoveries about CNTNAP2's role in brain calming in patients with autism and epilepsy may lead to new treatments


    "We can replace CNTNAP2," said Peter Penzes, lead author of the study and director of the Center for Autism and Neural Development at Northwestern University's Feinberg School of Medicine


    Penzes's laboratory is currently working on preclinical research on this technology


    The level in the spinal cord represents the level in the brain, Penzes said


    When brain cells become too active due to overstimulation, they will produce more CNTNAP2, and CNTNAP2 will drift away and combine with other brain cells to calm them down



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