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The sedative brain protein is very low in autistic patients, causing epilepsy
Because of genetic mutations, the brain has not stopped being overactive
30-50% of children with autism also suffer from epilepsy
Why do so many children with autism often suffer from epilepsy? Scientists from Northwestern Medical Corporation have discovered an important brain protein that can quiet overactive brain cells.
This protein can be detected in the cerebrospinal fluid, making it a promising marker for diagnosing autism and treating epilepsy that accompanies autism
Scientists know that once this gene is mutated, it can lead to autism and epilepsy
This protein called CNTNAP2 is appropriately called "catnap2" and is produced when brain cells are overactive
In this study, Penzes and his colleagues analyzed the cerebrospinal fluid in autism and epilepsy patients and mouse models
The research will be published in the December 17th issue of Neuron
New discoveries about CNTNAP2's role in brain calming in patients with autism and epilepsy may lead to new treatments
"We can replace CNTNAP2," said Peter Penzes, lead author of the study and director of the Center for Autism and Neural Development at Northwestern University's Feinberg School of Medicine
Penzes's laboratory is currently working on preclinical research on this technology
The level in the spinal cord represents the level in the brain, Penzes said
When brain cells become too active due to overstimulation, they will produce more CNTNAP2, and CNTNAP2 will drift away and combine with other brain cells to calm them down