echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Biochemistry News > Biotechnology News > Neuron 'repair agent' may be 'part-time' to treat infertility

    Neuron 'repair agent' may be 'part-time' to treat infertility

    • Last Update: 2022-04-30
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    On February 17, "Nature Communications" published a study by Chinese scholar Professor Lu Bai from the School of Pharmacy of Tsinghua University.


    Lu Bai's team has been working to find potential drugs to treat nerve damage


    The team unexpectedly discovered that this antibody drug, which can activate a specific target, can also promote oocyte maturation and follicle development in the non-nervous system


    Problems with oocyte maturation and follicle development have long plagued women with infertility


    So can this drug be symptomatic? The data show promise


    Previous clinical data revealed that patients with premature ovarian failure showed a significant decrease in the level of brain-derived neurotrophic factor in the plasma, and there were also papers that showed that genetic variants of brain-derived neurotrophic factor increased the risk of premature ovarian failure


    In order to verify whether the neuron "repair agent" can restore fertility, the team began to conduct experiments on animal models


    The researchers used two disease models of premature ovarian failure to test the efficacy of the drug


    Studies have shown that in two animal models of premature ovarian failure, treatment with new antibody drugs can effectively maintain and promote follicle development, restore hormone homeostasis, and inhibit ovarian cell apoptosis


    Finally, in order to explore the therapeutic application of drugs to patients with premature ovarian failure, the researchers used single-cell sequencing technology to analyze the gene expression of the target TrkB in female oocytes and granulosa cells.


    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.