NEURON: Researchers map AD risk network

There is evidence of interactions between the three major risk factors for Alzheimer's disease (AD): age, APOE genotype, and sexrecently, researchers demonstrated a comprehensive data set and analysis of brain transcription and blood metabolism groups from humanized apoE2,apoE3-, and apoE4-targeted replacement mice of different ages and gendersresearchers found that age had the greatest effect on the brain transcription group, particularly in the immune modules led by Trem2 and Tyrobp, and that apoE4 was associated with an increase in multiple Serpina3 genesimportant, these changes in networks and gene expression are mostly conservative in the human brainfinally, the researchers observed significant interactions between age, APOE genotype, and sex on the unfolded protein response pathwayIn the peripheral week, APOE2 drives different blood metabolism group spectra, highlighting an increase in lipid metabolitestherefore, the work identified unique, interactive molecular pathways that provide valuable resources for discovery and validation studies in model organisms and humans