echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Study of Nervous System > Neuron: Scientists have discovered a special cell type that is involved in the body's neuropathic pain-MRC1+ macrophages!

    Neuron: Scientists have discovered a special cell type that is involved in the body's neuropathic pain-MRC1+ macrophages!

    • Last Update: 2021-03-23
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    March 8, 2021 // One of the main signs of chronic pain is inflammation.


    Neuron

    In the article, the researchers stated that stimulating the expression of an anti-inflammatory protein called CD163 may reduce signs of neuropathic inflammation in the spinal cord of mice with neuropathic pain.


    Image source: Zylka Lab, UNC School of Medicine

    According to US CDC data, about one-fifth of Americans suffer from chronic pain.


    In this study, the researchers used single-cell RNA sequencing technology to analyze thousands of cells at a time to observe which cells have changed during chronic pain in the body, and which methods of cells have changed.


    Researcher Niehaus said, this may be very interesting, because long-term inflammation of the spinal cord is very common in animal models of neuropathic pain; as the identity of the new type of macrophages has been elucidated, the researchers have also used a gene therapy to stimulate the MRC1+ giant The expression of an anti-inflammatory protein called CD163 in phages, based on this method, can reduce the inflammation of the host's spinal cord after one treatment, and can make this pain relief related behavior last up to one month.


    One of the main signs of chronic pain is inflammation.


    In the article, the researchers stated that stimulating the expression of an anti-inflammatory protein called CD163 may reduce signs of neuropathic inflammation in the spinal cord of mice with neuropathic pain.


    According to US CDC data, about one-fifth of Americans suffer from chronic pain.


    In this study, the researchers used single-cell RNA sequencing technology to analyze thousands of cells at a time to observe which cells have changed during chronic pain in the body, and which methods of cells have changed.


    Researcher Niehaus said, this may be very interesting, because long-term inflammation of the spinal cord is very common in animal models of neuropathic pain; as the identity of the new type of macrophages has been elucidated, the researchers have also used a gene therapy to stimulate the MRC1+ giant The expression of an anti-inflammatory protein called CD163 in phages, based on this method, can reduce the inflammation of the host's spinal cord after one treatment, and can make this pain relief related behavior last up to one month.


    Original source:

    Original source:

    Laurence D Picton, Maria Bertuzzi, Irene Pallucchi, et al.


    Laurence D Picton, Maria Bertuzzi, Irene Pallucchi, et al.
    ncbi.
    nlm.
    nih.
    gov/33577748/">A spinal organ of proprioception for integrated motor action feedback , Neuron (2021) doi:10.
    1016/j.
    neuron.
    2021.
    01.
    018 ncbi.
    nlm.
    nih.
    gov/33577748/">A spinal organ of proprioception for integrated motor action feedback Neuron
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.