【Neuron】Always scratching hair and skin when anxious? Shanghai Jiaotong Huangju team discovered a neuromodulation mechanism for self-grooming!

This article is the original of translational medicine network, please indicate the source when reprinting

Author: Mia

Body-centered repetitive behaviors (BFRBs) are conceptualized as a means

On September 6, The Huang Ju team at Shanghai Jiao Tong University published a research paper

DOI:https://doi.

Research background

 01 

Human body-centered repetitive behaviors (BFRBs) refer to a set of cyclical non-functional behaviors (such as pulling hair and scratching the skin)

Similar to human BFRBs, many animals self-groom when stressed

However, there is still controversy about the emotional effects of self-grooming, and it is unclear how repetitive behavior-related neurons connect and influence emotion regulation-related neurons

Research Overview

 02 

The medial paranucleus of rodents is located at the head of the pontine, bordering the auditory relay nucleus of the lateral thalamic system on the lateral side, the medial border with the mouth of the ponychia reticulated structure, and the ventral side bordering the red spinal cord bundle

In this study, the team found that MPL^SST neurons in mice respond to stress, promote self-grooming, and encode rewards

MPL^SST neurons control self-grooming and co-release neuropeptideSST and PTH2

The researchers also noted that neither hM4D-mediated MPL^SST neuronal inhibition nor caspase-3-mediated MPL^SST neuron ablation completely blocked self-grooming after stress exposure, suggesting that there are other mechanisms

Summary of the study

 03 

Self-grooming is a sensitive marker of stress levels in animals, and there is growing evidence to support the role of self-grooming in post-stress de-arousal

Taken together, the study provides new insights into the functions and circuits of MPL^SST neurons in controlling self-grooming and post-stress anxiety relief by activating the reward system, expanding our knowledge of

Resources:

DOI:https://doi.

Note: This article is intended to introduce the progress of medical research and cannot be used as a reference for

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