echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Biochemistry News > Biotechnology News > Neuron's first results: Pain and anxiety affect breathing at the cellular level

    Neuron's first results: Pain and anxiety affect breathing at the cellular level

    • Last Update: 2021-12-25
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com


    From left: Sung Han and Shijia Liu, Salk Institute

    You were startled by a threatening sound, and your breathing quickened; you broke your elbow and you were out of breath


    In this study published in the journal Neuron on December 17, 2021, Salk’s team focused on a group of neurons in the brainstem called the lateral parabrachial nucleus, which has a core-shell structure.


    "We are the first group to demonstrate how parabrachial nuclei coordinate breathing and pain," said Sung Han, senior author of the paper and assistant professor of the Salk Clayton Peptide Biology Clayton Foundation Laboratory


    In OIRD, opioids suppress breathing and pain; this is the main cause of death from opioids


    To show how these neurons coordinate breathing with pain and emotions, the researchers first used light and chemicals to prove that manipulating morr-expressing neurons in the lateral parabrachial nucleus can change the respiratory rate of mice


    "We have discovered very complex circuits involving upstream and downstream inputs of these neurons


    Han is eager to see that the team's findings can be translated into applications


    Han's team is currently conducting genetic analysis of the core and shell populations to determine specific functional markers that regulate pain or breathing



    Article title

    Divergent brainstem opioidergic pathways that coordinate breathing with pain and emotions

    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.