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You were startled by a threatening sound, and your breathing quickened; you broke your elbow and you were out of breath
In this study published in the journal Neuron on December 17, 2021, Salk’s team focused on a group of neurons in the brainstem called the lateral parabrachial nucleus, which has a core-shell structure.
"We are the first group to demonstrate how parabrachial nuclei coordinate breathing and pain," said Sung Han, senior author of the paper and assistant professor of the Salk Clayton Peptide Biology Clayton Foundation Laboratory
In OIRD, opioids suppress breathing and pain; this is the main cause of death from opioids
To show how these neurons coordinate breathing with pain and emotions, the researchers first used light and chemicals to prove that manipulating morr-expressing neurons in the lateral parabrachial nucleus can change the respiratory rate of mice
"We have discovered very complex circuits involving upstream and downstream inputs of these neurons
Han is eager to see that the team's findings can be translated into applications
Han's team is currently conducting genetic analysis of the core and shell populations to determine specific functional markers that regulate pain or breathing
Article title
Divergent brainstem opioidergic pathways that coordinate breathing with pain and emotions