New advances in DON-induced muscle cell damage and accurate detection of major derivatives

On October 1, 2021, the international academic journal Ecotoxicology and Environmental Safety published an online publication titled "Mycotoxin deoxynivalenol affects myoblast differentiation via downregulating cytoskeleton and ECM-integrin-FAK-RAC-PAK signaling" by the Wu Aibo research group of the Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences.
pathway" research paper
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The vast majority of research on deoxynivalenol (DON, commonly known as vomiting toxin) in the past mostly focused on its immunotoxicity, neurotoxicity, reproductive toxicity, genetic toxicity, etc.

https://authors.
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Figure 1.
Vomitoxin DON affects myotube formation in muscle cells

On September 16, 2021, the international academic journal Toxins published an online publication titled "Validation of LC-MS/MSCoupled with a Chiral Column for the Determination of 3- or 15-AcetylDeoxynivalenol Mycotoxins from Fusarium" by the Wu Aibo research group of Shanghai Institute of Nutrition and Health.
"Graminarum in Wheat" research paper
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3-, 15-ADON is the main derivative type of DON toxin.

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The above research has been supported by the National Key Research and Development Program, the National Natural Science Foundation of China, and the Shanghai Municipality.