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    Home > Chemicals Industry > New Chemical Materials > New biological material: Boron-containing sodium alginate hydrogel can shorten the recovery time of muscle injuries

    New biological material: Boron-containing sodium alginate hydrogel can shorten the recovery time of muscle injuries

    • Last Update: 2021-09-21
    • Source: Internet
    • Author: User
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    Text/Chen Gen Muscle injury is a common sports injury.
    Any exercise, if there is no warm-up, or scientific exercise, will cause muscle injury
    .
    Muscle injuries often require a long period of recovery.
    Recently, the research team from the University of Valencia (UPV) and CIBER Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) said that they designed and tested a system at a preclinical level.
    A new biological material used to treat and restore muscle injuries
    .
    This is a boron-containing sodium alginate hydrogel that can be injected subcutaneously
    .
    According to experiments conducted on animal models, it can regenerate damaged muscles very quickly, shortening the recovery time of injured muscles by half
    .
    The key to the high performance of this biomaterial is the release of boron, which is loaded in the hydrogel in a simple way
    .
    When released, it stimulates integrin, a protein present in all cells of the body, and plays a fundamental role in the adhesion of cells to the extracellular matrix, thereby regenerating tissues
    .
    Specifically, according to the research of UPV and CIBER-BBN team, stimulating the integrin that binds fibronectin and boron ion transporter (NaBC1) at the same time significantly promoted muscle regeneration
    .
    The reason is that it induces a greater number and larger size of adhesions in undifferentiated muscle cells.
    These cells participate in muscle regeneration after injury, which is ultimately conducive to the formation of differentiated myotubes, and differentiated myotubes are produced correctly.
    In laboratory experiments necessary for the new regeneration of muscle fibers, the researchers used the cobra snake venom (cardiotoxin, cobra snake venom) to induce acute injury in mice, and the activation of NaBC1 accelerated the process of muscle regeneration
    .
    The results confirmed that by adding boron to damaged muscle cells, their adhesion levels increased, and now they adhere in a faster and more powerful way, allowing muscles to regenerate in a shorter time
    .
    Therefore, this work proposes a simple and novel method to achieve muscle regeneration through the interaction between specific receptors on the cell membrane
    .
    With the support of this method, if the second degree fiber tear takes 30 days to regenerate, the hydrogel will help shorten the recovery time to 15 days
    .
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