New bone transplant biomass brings better smiles and less pain to patients

new bone transplant biomass formula, which is too cold before use, should make it easier for dental patients to meet their expectations for a good smile while reducing the pain associated with collecting bones from other parts of the body.

results were published in the April 2, 2020 issue of the Journal of Biomedical Materials Research Part B: Applied Biomass.

patients with missing teeth do not just want to regain function. Most importantly, they want to make up their teeth and make them smile.

"Patients' strict aesthetic requirements make the already difficult process for clinicians more challenging because of the complex anatomical structure of these parts of the mouth," said Shinji Kamakura, a professor at Northeastern University's Bone Regenerative Engineering Laboratory.

to overcome these challenges, clinicians tend to perform bone grafts using unnecessary bone grafts taken from other parts of the same patient, such as the chin or pelvis, a process known as an autobiographical transplant. Unfortunately, this requires an additional surgical site, which increases the patient's pain in that area, and there are only a very small number of non-essential bones!

synthetic alternatives made from minerals have appeared in humans, but have similar mechanical properties to bones and can sometimes be used in other types of bone transplants. However, these biomass substitutes have low bone regeneration properties compared to the gold standard for self-transplantation.

Due to the compression stress of the bone itself on the material, the conventional formulation of OCP/Col preparations will still experience problems with "same bone growth" or increased width, so OCP/Col is supported by the structure of the Teflon ring to maintain its shape as the bone forms. But Teflon is not a material that can be absorbed by the body and eventually needs to be removed.

To solve this problem, Professor Kamakura and his colleagues developed an OCP/Col formula that increases its density and cools liquid nitrogen to 196 degrees C before it is cooled, and then applied to rodent test subjects, allowing bone surgeons to maintain their shape.

now, researchers plan to test the formula in larger animals and then conduct clinical trials in humans.

Over the past fifteen years, a new alternative bone substitute, octa calcium phosphate, has provided the basis for the mineral crystals that make up the bones, and because it has better bone regeneration properties than earlier alternatives, it appears to be combined with collagen (OCP/Col) as a possible candidate. After many years of clinical trials, the commercialization of OCP/color in oral surgery was recently approved in Japan. （cyy123.com）