A new compound that inhibits AChE in Alzheimer's disease has been discovered

Recently, yaghoub pourshojaei and other scientists from the University of Coleman in Iran reported their research on the derivatives of Alzheimer's disease treatment drugs The report said that a compound containing phenoxyethylamine has an inhibitory effect on acetylcholinesterase They hope that the research results can be some inspiration for the future research of Alzheimer's disease drugs The report is published in nature According to the 2018 World Alzheimer's report, every three seconds there will be a new case of Alzheimer's disease (AD) In 2018, there will be about 50 million people suffering from Alzheimer's disease Researchers predict that by 20501, the number will double Alzheimer's disease accounts for more than two-thirds of all dementia cases and is the fifth leading cause of death in the world in 2018 Compared with cardiovascular disease, cancer and HIV, the lack of research literature on Alzheimer's disease (from the results of major scientific search engines, Alzheimer's disease data is significantly lower than cardiovascular disease, cancer and HIV), as well as the lack of confirmed physiological and pathological mechanisms of human diseases, leading to the lack of effective treatment for Alzheimer's disease Source: doi.org/10.1038/s41598-019-56463-2 Acetylcholinesterase (AChE) is a key enzyme in biological nerve conduction Among cholinergic synapses, ache can degrade acetylcholine, terminate the excitatory effect of neurotransmitters on postsynaptic membrane, and ensure the normal transmission of nerve signals in vivo Acetylcholine is related to memory The cholinergic system of the central nervous system needs enzymes to participate in the synthesis of acetylcholine Acetylcholine invertase is an essential enzyme for the synthesis of acetylcholine In Alzheimer's disease, the level of acetylcholine invertase decreased, and the synthesis and release of acetylcholine decreased, which affected the normal memory and cognitive function However, it was found that the enzyme that breaks down acetylcholine also decreased Acetylcholinesterase catalyzes the transformation of a β peptide to aggregation state, and PAS, the peripheral anion site of ache, is involved in this process CAS, the catalytic site of donepezil, stimulates the decomposition of acetylcholine (ACh) and the consumption of ACh in synapses in AD patients Yaghoub pourshojaei et al Studied and synthesized a series of compounds containing phenoxyethylamine, and tested the inhibition of these compounds on the activities of acetylcholinesterase and butyrycholinesterase of electric eel and horse Then, the best compound combined with cholinesterase in human body was studied by molecular dynamics method, and compared with donepezil.