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    Home > Biochemistry News > Biotechnology News > New Cell Insights: New signals that trigger the body's immune response

    New Cell Insights: New signals that trigger the body's immune response

    • Last Update: 2022-10-03
    • Source: Internet
    • Author: User
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    Image: Researchers at the Cleveland Clinic's Florida Center for Research and Innovation have found that the destruction of cellular structures known as actin cytoskeletons is a "start-up signal" for the body to respond to the virus



    Previously, viral genetic material like RNA was thought to be the only requirement for certain sensor molecules living in cells to trigger an immune response — an "alert system"


    "This is a fundamental new way to consider how to activate the immune system, and the implications are to lead to widespread antiviral therapy," said Michaela Gack, director of science at FRIC


    The cytoskeleton, which is made up of actin, is the structural support of the cell, but also plays a key role


    Dr Gack said: "Whether our cellular immune surveillance system can sense this process and trigger an antiviral response is unclear


    Despite being around for decades, interest in RNA as the basis for vaccines and treatments has grown


    Dr.


    Gack's lab studies virus-host interactions at the molecular level, identifying host responses that can play a key role in developing new therapies and vaccines


    essay

    Actin Cytoskeleton Remodeling Primes RIG-I-like Receptor Activation

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