The latest "Cell": Immune cells like antibodies are more important than antibodies to fight against acute new crown infections?

From the point of view of the system, the vaccine can induce the human body to produce neutral antibodies, to produce a protective immune response.
but antibodies and the B cells that produce them are only part of the human adaptive immune system.
addition to B cells, the immune system includes killer T cells and auxiliary T cells.
although all three types of cells are involved in the fight against viral infections, past new crown-related studies have focused on antibodies, with relatively few studies on the function of both types of T-cells.
hours earlier, Cell published a paper online that said fighting the new coronavirus requires the concerted involvement of the entire adaptive immune system.
, T cells may be more important than antibodies.
study, scientists analyzed blood samples from 50 new crown patients, including those with acute infections and rehabilitation, to see how antibodies, killer T-cells, and auxiliary T-cells each worked in these patients.
analysis found that the three pillars of the adaptive immune system were intact in patients who were fully recovered.
in patients with acute infection with the new coronavirus, antibodies, killer T-cells, and auxiliary T-cells are missing one or more.
addition, the researchers note that the new coronavirus-specific killer T-cells and auxiliary T-cells are associated with milder diseases.
addition, coordination between the three is also associated with milder diseases.
these results show that killer and auxiliary T cells can also produce protective immunity to new coronavirus.
when we looked at the data from 111 measurable dimensions, we found that, in general, the broader and more coordinated a person's adaptive immune response, the better it recovers."
In particular, the powerful T-cell response specific to the new coronavirus is predictive of minor diseases," said Study co-co-founder Dr Carolyn Moderbacher.
based on this observation, we can also explain why neo-coronary disease is more severe in people over 65 years of age.
researchers point out that individual T-cells over the age of 65 generally respond worse and the immune system is less coordinated, potentially making coronary disease more serious and deadly.
they speculate that this may be related to the reduction of childish T-cells in older adults.
these cells are like reserves of T-cells, and the smaller the number, the less immune forces they can mobilize.
map of this study (Photo Source: References; Crotty Lab/Cell Press) The researchers note that antibodies do not appear to play an important role in acute neo-coronavirus infections, with primary immune protection coming from auxiliary T cells and killer T cells.
but the researchers also point out that this does not mean that antibodies are not important.
"some people may be confused," said Professor Shane Crotty, one of the study's co-authors.
the latter allows our immune system to react the first time.
" Reference: s1. Carolyn Rydyznski Moderbacher et al., (2020), Antigen-specific adaptive immunity to SARS-CoV-2 in acute COVID-19 and associations with age and disease severity, Cell, DOI: