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    Home > Biochemistry News > Biotechnology News > New CRISPR/Cas9 technology can correct cystic fibrosis of cultured human stem cells

    New CRISPR/Cas9 technology can correct cystic fibrosis of cultured human stem cells

    • Last Update: 2021-08-13
    • Source: Internet
    • Author: User
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    Image: Patient's mini-intestinal swelling reaction



    Researchers at Hans Clevers (Hubrecht Institute) corrected the mutation that caused cystic fibrosis in cultured human stem cells


     Cystic fibrosis (CF) is one of the most common genetic diseases in the world, with serious consequences for patients


    Correct CF mutation

    The researchers successfully corrected the mutations that cause CF in human intestinal organoids


    Safer than CRISPR/Cas9

    Start-up editing is an updated version of the more widely known gene editing technology CRISPR/Cas9


    swelling

    The mutation that causes CF is located in the CFTR channel, which is present in cells of various organs including the lung


    Treatment of genetic diseases

    Now, researchers have shown that the mutations that cause CF can be safely corrected, and the clinical application has taken another step forward


    DOI

    https://doi.


    Article title

    Evaluating CRISPR-based Prime Editing for cancer modeling and CFTR repair in organoids

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