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    Home > Medical News > Latest Medical News > New crown variant B.1.1.7 kit, 1 hour identification

    New crown variant B.1.1.7 kit, 1 hour identification

    • Last Update: 2021-01-12
    • Source: Internet
    • Author: User
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    the new crown mutant strain B.1.1.7, which was first reported by the UK, has spread to many countries, raising further concerns about the outbreak.
    January 5, Shenzhen Huada Gene Co., Ltd. ("Huada Gene"), a holding subsidiary of Shenzhen Huada Gene Co., Ltd. ("Huada Gene"), announced that the company has developed a new coronavirus SARS-CoV-2 B.1.1.7 strains (N501Y) rapid identification kit.
    Huada Source said that for the new coronavirus test positive cases, the B.1.1.7 type of major mutation point N501Y can be further rapid identification diagnosis, completed within an hour.according to
    , the kit uses ARMS-qPCR method, design-specific amplification for B.1.1.1.7 core mutation points N501Y in the United Kingdom, combined with fluorescent probe signals, to quickly identify wild and mutant strains, can achieve the identification and diagnosis of wild virus strains (501N) and mutant strains (501Y).
    previously, on 14 December 2020, the UK was the first to inform the World Health Organisation (WHO) of the emergence of a new strain of the new B.1.1.7 coronavirus.
    10 scientists, including Andrew Rambaut of the University of Edinburgh, Nick Loman of the University of Birmingham and David L Robertson of the Centre for Virus Research at the University of Glasgow, represented the UK's COVID-19 Genomics Alliance (CoG-UK) on the virology website (virology.org) The first genome samples of the two B.1.1.7 genealogies were collected in Kent on 20 September 2020 and the other in Greater London on 21 September 2020.
    10 scientists mentioned that the B.1.1.7 genealogy is based on the D614G strain, but carries an unusually large number of viral genetic changes. The strain has 23 special mutations, including 14 non-synonymic mutations (amino acid changes), 3 missing, and 6 synonym mutations (non-amino acid changes). This is the first time so far that so many mutations have appeared on a strain.
    three of these mutations have potential biological effects, which have been described before. The first is the N501Y mutation, which is one of six key contact residuals in the subject binding domain (RBD) and has been identified as increasing binding affinity with human and mouse ACE2. Scientists have also speculated that the B.1.1.7 strain is 70 percent more contagious, most likely related to the N501Y mutation.
    WHO noted in a briefing that while preliminary assessments indicate that the new B.1.1.7 coronavirus strain does not increase the severity of the disease, it can lead to higher morbidity, more hospitalizations and deaths, and that more stringent public health measures are needed to control the spread of these variants. WHO recommends that countries increase surveillance of new coronavirus to better understand the spread of the virus and monitor variants.
    It is worth noting that on January 1st, the Shanghai Cdcs for Disease Control and Prevention announced that it had recently sequenced the genomes of confirmed cases of new coronary pneumonia imported into the United Kingdom and found that the genetic sequence of the new coronavirus in one case was similar to the mutated virus gene recently reported in the United Kingdom.The Department of Health announced on 2 January that, as of 0:00 a.m. on 2 January, a total of 10 imported cases of viral genetic sequencing had been found to match the mutated new coronavirus strain found in the United Kingdom and two with the mutated new coronavirus strain found in South Africa.
    January 3, the Guangdong Provincial Center for Disease Control and Prevention announced that on January 2, the CDC found a variant of B.1.1.7 in a swab sample of a confirmed case of newly crowned pneumonia in the United Kingdom, highly similar to the genetic sequence of the mutated virus recently reported in the United Kingdom.
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