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This article is from NEJM Journal Watch New Definition of Metabolically Healthy Obesity.
Comment by Thomas L.
Schwenk, MD.
In obese people, blood pressure, diabetes and waist-to-hip ratio are related to cardiovascular risk.
The most closely related variable
.
The concept of metabolically healthy obesity is controversial
.
In this study, the researchers proposed a new definition based on two large-scale population prospective cohort studies on healthy behaviors and outcomes (386,000 participants; average ages of 42 and 56 years; average body mass index [BMI] is the data in 27 kg/m2)
.
The researchers followed the two cohorts for an average of 8 and 15 years, during which 2,600 cardiovascular disease-related deaths occurred
.
In the adjusted analysis, participants with BMI≥30 kg/m2, systolic blood pressure <130 mmHg without antihypertensive drugs, no diabetes, and waist-to-hip ratio <0.
94 (female) or <1.
03 (male) Excessive risk of cardiovascular disease or death
.
The prevalence of metabolically healthy obesity was 41% in one cohort and 19% in the other cohort
.
Comment on this exploratory study that may help clinicians answer the following questions of obese patients: What is their risk of cardiovascular disease in the absence of significant metabolic dysfunction? This study again focuses on waist-to-hip ratio, which has received much attention before, that is, the risk of cardiovascular disease associated with the "pear-shaped" body is lower than the risk of cardiovascular disease associated with the "apple-shaped" body
.
Commented article Zembic A et al.
An empirically derived definition of metabolically healthy obesity based on risk of cardiovascular and total mortality.
JAMA Netw Open 2021 May 7; 4:e218505.
(https://doi.
org/10.
1001/jamanetworkopen.
2021.
8505 ) NEJM Journal Watch is published by NEJM Group.
Internationally renowned doctors are invited to comment on important papers in the medical field to help doctors understand and use the latest developments
.
"NEJM Frontiers of Medicine" is translated several times a week, published on the app and official website, and selected 2-3 articles are published on WeChat
.
Copyright information This article was translated, written or commissioned by the "NEJM Frontiers of Medicine" jointly created by the Jiahui Medical Research and Education Group (J-Med) and the "New England Journal of Medicine" (NEJM)
.
The Chinese translation of the full text and the included diagrams are exclusively authorized by the NEJM Group
.
If you need to reprint, please leave a message or contact nejmqianyan@nejmqianyan.
cn
.
Unauthorized translation is an infringement, and the copyright owner reserves the right to pursue legal liabilities
.
Comment by Thomas L.
Schwenk, MD.
In obese people, blood pressure, diabetes and waist-to-hip ratio are related to cardiovascular risk.
The most closely related variable
.
The concept of metabolically healthy obesity is controversial
.
In this study, the researchers proposed a new definition based on two large-scale population prospective cohort studies on healthy behaviors and outcomes (386,000 participants; average ages of 42 and 56 years; average body mass index [BMI] is the data in 27 kg/m2)
.
The researchers followed the two cohorts for an average of 8 and 15 years, during which 2,600 cardiovascular disease-related deaths occurred
.
In the adjusted analysis, participants with BMI≥30 kg/m2, systolic blood pressure <130 mmHg without antihypertensive drugs, no diabetes, and waist-to-hip ratio <0.
94 (female) or <1.
03 (male) Excessive risk of cardiovascular disease or death
.
The prevalence of metabolically healthy obesity was 41% in one cohort and 19% in the other cohort
.
Comment on this exploratory study that may help clinicians answer the following questions of obese patients: What is their risk of cardiovascular disease in the absence of significant metabolic dysfunction? This study again focuses on waist-to-hip ratio, which has received much attention before, that is, the risk of cardiovascular disease associated with the "pear-shaped" body is lower than the risk of cardiovascular disease associated with the "apple-shaped" body
.
Commented article Zembic A et al.
An empirically derived definition of metabolically healthy obesity based on risk of cardiovascular and total mortality.
JAMA Netw Open 2021 May 7; 4:e218505.
(https://doi.
org/10.
1001/jamanetworkopen.
2021.
8505 ) NEJM Journal Watch is published by NEJM Group.
Internationally renowned doctors are invited to comment on important papers in the medical field to help doctors understand and use the latest developments
.
"NEJM Frontiers of Medicine" is translated several times a week, published on the app and official website, and selected 2-3 articles are published on WeChat
.
Copyright information This article was translated, written or commissioned by the "NEJM Frontiers of Medicine" jointly created by the Jiahui Medical Research and Education Group (J-Med) and the "New England Journal of Medicine" (NEJM)
.
The Chinese translation of the full text and the included diagrams are exclusively authorized by the NEJM Group
.
If you need to reprint, please leave a message or contact nejmqianyan@nejmqianyan.
cn
.
Unauthorized translation is an infringement, and the copyright owner reserves the right to pursue legal liabilities
.