New development of "artificial pancreas": comprehensive improvement of blood sugar control in "elderly type 1 diabetic patients"

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Recently, according to a report published in "Diabetes Technology and Therapeutics": The use of a hybrid closed-loop insulin delivery system is related to better blood sugar control in elderly patients with type 1 diabetes
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Schematic diagram of artificial pancreas (Source: Dual-hormone artificial pancreas for management of type 1 diabetes: Recent progress and future directions) What is "artificial pancreas"? In recent years, with the development of electronic technology, providing diabetic patients with a device that mimics the pancreas and provides insulin as much as possible has become a research hotspot
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Artificial pancreas (artificial pancreas) refers to a device that uses electronic machinery to replace the endocrine function of the pancreas to control blood sugar within the physiological range
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Because pancreatic islets are the main part of the pancreas to perform endocrine functions, the device is more accurately called artificial pancreatic islets, but the name "artificial pancreas" is still commonly used at home and abroad
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Artificial pancreas has the advantages of real-time regulation of blood sugar, high safety, and less skin irritation.
During use, patients only need to place a tube under the skin, which not only avoids repeated stimulation and damage to the skin, but also eliminates the need for repeated regular injections of insulin
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Therefore, the research and development of artificial pancreas is a great boon for diabetic patients
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Schematic diagram of artificial pancreas (source: US FDA official website) Latest research progress: use of artificial pancreas in the elderly.
Researchers analyzed the data of 46 type 1 diabetic patients aged ≥65 years old who used Control-IQ hybrid in 2020 Closed loop system
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Both clinical information and continuous blood glucose monitoring data come from electronic medical records
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In the study cohort, 37 participants used a closed-loop control system (36 people have a history of insulin pump use, 35 people have used CGM before)
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Blood glucose control is improved.
After using the closed-loop system: ➤TIR (glucose in the target range time) increased from 62% to 76% (P<0.
001); ➤TBR (glucose lower than the target range time) from 2% to 1% (P =0.
03); ➤TAR (glucose higher than the target range time) from 30% to 20% (P＜0.
001); ➤The time for severe hypoglycemia or severe hyperglycemia did not change; ➤The coefficient of variation of blood glucose was significantly improved (35 % vs.
27%, P=0.
001); ➤HbA1c index dropped from 7% to 6.
8% (P=0.
002)
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Researchers with good patient compliance mentioned: “Due to the epidemic, the isolation restricts face-to-face guidance, which may affect patient compliance and doctors’ clinical decision-making
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However, in this context, most participants can use it well The equipment
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"References: [1]Toschi E, et al.
Diabetes Technol Ther.
2021;doi:10.
1089/dia.
2021.
0311; [2]Michael Monostra.
Artificial pancreas improves glycemic control for older adults with type 1 diabetes[EB/OL] .
[2021-12-17].
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