New development of medical 3D printing technology in 7 fields

[China Pharmaceutical network industry trends] this paper mainly observed the new progress of medical 3D printing technology in the following 7 fields in the quarter of 2017 (new development of medical 3D printing technology in 7 fields picture source: Baidu picture) the pharmaceutical and biological industry is currently a rapid expansion of 3D printing technology 3D printing technology can provide a more complete personalized solution for the medical and biological industry; biological 3D printing technology will promote the research of regenerative medicine in the field of artificial living tissues and organs In terms of personalized solutions, typical applications include 3D surgical pre planning model, surgical guide plate, 3D printing implants, prostheses, hearing aids and other rehabilitation medical devices In the field of regenerative medicine, researchers have made positive progress in using biological 3D printing technology to cultivate artificial surface This paper mainly observed the new progress of medical 3D printing technology in the following 7 fields in the quarter of 2017 Operation planning model is very important for the operation with high risk and difficulty Traditionally, it is the basis of pre planning for doctors to obtain patients' data through CT, MRI and other imaging equipment, but the medical image obtained is two-dimensional, and then it needs to use software to transform the two-dimensional data into realistic three-dimensional data The 3D printer can print the 3D model directly, which can not only assist the doctors to plan the operation, improve the success rate of the operation, but also facilitate the doctors and patients to communicate directly on the operation plan In addition, even if the treatment fails, 3D printing can provide traceable basis for both doctors and patients The world's first breast reconstruction assisted by Mr hybrid reality technology In March 2017, doctors of Hunan Cancer Hospital wore hololens glasses that had input 3D image information of patients during the operation The personalized design of 3D blood vessel data before the operation cut the medial femoral perforator flap with an area of 22cm * 14cm for free transplantation to reconstruct the breast The operation took six hours to complete safely and smoothly In early March, a medical team in Krakow, Poland, demonstrated the internal tumor and internal circulation system of the liver, and referred to the problems that surgeons may face The researchers took a 52 year old female patient's liver as a sample, first obtained a CT scan of her liver, and then used a standard 3D printer of PLA color materials to print six parts Then the scaffold of liver parenchyma scaffold was constructed and filled with silica gel After the completion of the model, the liver can be clearly seen, including shape, mass, tumor and some internal blood vessels The total cost is about 160 hours, and the model cost is less than $150 Compared with the research conducted by the research team of Tsukuba University in Japan in 2015, this 3D liver model brings the cost to an acceptable level, which can be borne by most patients The customized treatment plan is also helpful for the improvement of the operation success rate 3D printing heart model saves the lives of infants in Los Angeles When 18 month old Nate Yamane began to endanger his life due to the narrowing of heart and pulmonary arteries, pediatric cardiologist Frank ing realized that he needed a stent, a small reticular tube for the treatment of narrow or weak arteries Using Nate's cardiac CT scan data, the hospital team created a 3D printed model of the blocked area Dr ing created a special small stent to accommodate 3D models from stenosed arteries The results were successful: Nate's oxygen levels improved overnight The first 3D printing spine replacement was completed in Guangdong Province The osteooncology team of the Third Affiliated Hospital of Southern Medical University (Guangdong orthopedic hospital) successfully removed the spine of a chordoma patient and implanted the 3D printing artificial vertebral body This is the first 3D printing spine replacement operation completed in Guangdong Province Personalized 3D printing of artificial spine is more conducive to the protection of nerves and bone healing 2 Surgical guide plate surgical guide plate is an auxiliary surgical tool which can accurately carry out the pre planning scheme in the operation It has applications in many disciplines, such as: joint guide, spine guide, dental implant guide, and guide positioning guide for implantation of internal radiation source particles in tumors Materialise is licensed by FDA to manufacture pediatric 3D printing surgical guides, which means children with congenital bone disease or bone injury can get better treatment The 3D printing guide is three-dimensional Based on the scanning data of the patient's bones, doctors can get real information, so as to better plan the operation In addition, the manufacturing cost is not high, even for ordinary patients Implants: some implants are made by casting or traditional metal processing methods, and need to make a mold first For only one or a small number of implants, a single production cost is very expensive Combined with the high price of biocompatible implants, the total manufacturing cost of orthopedic implants is very expensive For special implants with complex structure, it is difficult to use traditional technology 3D printing technology can effectively reduce the manufacturing cost of customized and small batch implants, and can produce more complex implants In recent years, more and more metal 3D printing technology (direct metal laser sintering or electron beam melting) is used in the medical industry to design and manufacture medical implants With the cooperation of doctors and engineers, 3D printing technology can produce more advanced and qualified implants and prostheses 3D printing technology also improves the delivery speed of customized implants, which can be completed within 24 hours from design to manufacturing Through the X-ray, MRI, CT and other medical image files provided by the hospital, the engineer establishes the three-dimensional model and designs the implant, and finally makes the design file through the metal 3D printing equipment OPM's 3D printed bone implant has been approved in Europe Oxford high performance materials (OPM) "customized implants for bone replacement" will utilize the emerging osteofab implant manufacturing process OPM will now apply its high-performance additive manufacturing process to 3D printing customized implants to perform bone replacement operations The Europe was first submitted at the end of 2011, took effect on December 21, 2016 and will last until August 7, 2029 Currently, OPM is also a 3D printing patient-specific polymer based implant approved by fda510 (k) Australia has successfully implemented the first 3D printed titanium polymer sternum implant CSIRO, Australia, anatomics, Melbourne medical implant company, and British doctors have jointly implemented the 3D printed titanium polymer sternum implant for a 61 year old British patient Edward Evans, which is also the world's first Previously, the implants were usually made of pure titanium The new sternum implants can help reconstruct the "hard and soft tissue" of human body better than the previous pure titanium implants Evans was discharged only 12 days after surgery and is now recovering rapidly Doctors at the medicity hospital in medanta, India, asked a 32-year-old woman who had been suffering from spinal tuberculosis to walk again It's also the kind of surgery that India does The cervical vertebrae of the female patient's section, the second section and the third section were severely damaged, which means that there was no bone support between her skull and the lower cervical vertebrae With the help of advanced metal 3D printing technology, doctors have printed a titanium vertebra in 3D and replaced the damaged part in the patient's spine with it, thus effectively filling the gap between the cervical vertebra and the fourth cervical vertebra The operation lasted a total of 10 hours This is the third such operation in the world Patients implanted with 3D printed spine have been able to ride a bicycle On June 12, 2016, the world 3D printed spine implantation operation was completed in the Third Hospital of Beijing Medical College CT of the patient in early January 2017 showed that the 19 cm long 3D printed implant implanted at that time was stably connected with his original spine, high-density shadow could be seen at the junction of the implant and spine, and there was evidence of bone fusion Gulou Hospital pioneered 3D printing and navigation in the treatment of sphenoidal neuralgia The team of Nanjing Gulou Hospital carried out a thin-layer CT scan of the patient's head, designed and 3D printed a personalized navigation template for the intervention of the sphenoidal ganglion During the operation, the template was used to guide the puncture to the target point, and a small amount of local anesthetics were used to complete the blocking of the sphenoidal ganglion When the blocking was completed, the patient immediately felt the sense of nasal obstruction and the sense of eye swelling, and the persistent pain in the left face was also relieved Obviously improved Subsequently, the team used the navigation template to conduct one-time radiofrequency treatment and two-time block treatment of the sphenoidal ganglion pulse, and the pain in the left side of the patient completely disappeared 3D printing personalized navigation template not only greatly shortens the operation time and reduces the trauma of the operation, but also greatly helps the patients who need multiple operations 4 Rehabilitation medical equipment is the same as 3D printing titanium alloy customized airplane parts and super car running personalized parts Prosthetic, hearing aid and other rehabilitation medical equipment also have small batch and customized requirements, and the design is complex Traditional CNC machine tools are often difficult to achieve due to processing angle and other factors In addition, the cost of making a single customized rehabilitation aid using 3D printing technology will be significantly reduced The promotion of 3D printing rehabilitation medical devices requires the intervention of professional medical device service providers, and professional operation from data collection, design, molding and product certification In the history, small 3D printing custom titanium hearing aid came out Phonak and Environtec, a German 3D printing company, jointly developed custom titanium hearing aid virtob titanium The highlight of this mode is that the shell and main parts are 3D printing, and the shell is not made of traditional hearing aid shell acrylic acid, but made of titanium metal with lighter weight and higher strength Therefore, the thickness of the shell is reduced by 50% (0.2mm) under the same safety level Through 3D printing technology, not only the time of hearing aid customization is greatly shortened (it is understood that the equipment can produce 65 hearing aid shells or 45 ear molds within one hour), but also the ear canal shape of hearing impaired people will be more suitable This technology is almost not affected by the technical gap of traditional ear mold makers The application of 53d printing in stomatology the cost of dental repair and treatment is an important factor for dental clinics and laboratories to consider Many prescient dental clinics and laboratories have introduced digital oral technology to improve efficiency and reduce costs In recent years, software design based dental restoration has become popular, and many dental clinics, laboratories or professional denture manufacturers have introduced 3D printing technology The digital oral technology combined with 3D printing has brought the dental industry with high precision, low cost, high efficiency, and the oral data consistent with the standardized production chain Many dental clinics or laboratories use 3D printers to make dental models of patients The three-dimensional data needed to make the model can be collected by directly scanning the mouth (it takes about 2 minutes to scan the whole mouth), or by indirectly scanning the traditional physical model Dental 3D models can be used as molds