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    Home > Active Ingredient News > Infection > New discovery: anti-androgen drugs "disarm" the spikes on the crown of the new crown virus

    New discovery: anti-androgen drugs "disarm" the spikes on the crown of the new crown virus

    • Last Update: 2021-06-18
    • Source: Internet
    • Author: User
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    A public welfare academic platform initiated by overseas returnees to share information, integrate resources and exchange academics, occasionally Fengyue Recently, a new research result from the University of Pennsylvania explains the mechanism and process of anti-androgen drugs destroying the key receptors required by the new coronavirus invading cells
    .

    This shows that anti-androgen drugs can "disarm" the spike protein of the coronavirus so that it cannot enter the host cell, thereby blocking the progress of the new coronary pneumonia disease
    .

     Epidemiological data show that the severity and mortality of men infected with new coronary pneumonia are higher than women
    .

    This reminded the research team that androgens may play a role in the new coronary pneumonia infection
    .

    As previous studies have proved, the entry of coronavirus into cells requires the "spike" on the surface of the virus-the binding of the spike protein to the cell receptor to penetrate the cell and enter the cell
    .

    Therefore, the Abramson Cancer Center research team aimed at this point and started research
    .

    The research team decided to use a fake SARS-CoV-2 for experiments
    .

    This pseudotyped SARS-CoV-2 carries the spike protein of the virus, but does not carry its genome
    .

    In mouse cells where androgen levels were significantly reduced after anti-androgen treatment, the researchers found that TMPRSS2 and ACE2 were almost not expressed, indicating that both were regulated by hormones
    .

    "Our research shows that in mouse and human cells, androgens regulate the transcription of SARS-CoV-2 host cell receptors ACE2 and TMPRSS2
    .

    This shows that the anti-androgen drugs used in the experiment can keep the virus out of the cell, thereby preventing or reducing the occurrence of the disease
    .

    "The first author of the paper, Professor Irfan A.
    Asangani of the University of Pennsylvania said
    .

    The anti-androgen drug used by the research team-Camostat (Camostat) is a drug developed and approved for marketing in Japan in the 1980s.
    TMPRSS2 is used to treat pancreatitis
    .

    Later, in the anti-androgen therapy for the treatment of prostate cancer, it was discovered that camostat can successfully prevent the virus from entering the lung and prostate cells, so it became one of the solutions for the treatment of prostate cancer
    .
    The
    research team found that, Camostat is also effective in fighting the new                    coronavirus
    .

    Studies have shown that the inhibition of TMPRSS2 by Camostat blocks the cleavage of the pseudotyped SARS-CoV-2 spike protein without disrupting the interaction between TMPRSS2 and ACE2, for the first time Prove that TMPRSS2 plays a direct role in initiating the SARS-CoV-2 spike protein, which is necessary for the fusion of the virus with the host cell
    .

    Through androgen deprivation therapy, or the use of anti-androgens such as camostat can prevent the virus from entering the host Cells
    .

    This discovery provides a new idea of ​​the molecular mechanism of the new coronavirus
    .

    In March of this year, Brazilian researchers tried to use a new anti-androgen therapy-isovaleramide (proxalutamide) in a clinical trial to treat the new coronavirus.
    Pneumonia
    .
    The
    preliminary results of 600 hospitalized patients showed that compared with standard treatment, the drug reduced the risk of death by 92% and shortened the length of hospital stay by an average of 9 days
    .

    In this regard, the research team believes that anti-androgen drugs alone or in combination with antiviral drugs can prevent the development of new coronary pneumonia as early as possible in the clinic
    .

    Next, the research team is going to continue in-depth research, use live SARS-CoV-2 to carry out experiments, and test the ability of anti-androgen therapy to block different variants of the virus
    .

    We will wait and see what the result will be
    .

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