New efficacy of betalodine: improving the cognitive function of mice with Alzheimer's disease
Last Update: 2020-06-19
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Alzheimer's disease (AD), also known as Alzheimer's disease, is a kind of neurodegenerative disease with concealed onset and chronic progressionThe main clinical manifestations are progressive memory disorder, cognitive dysfunction, personality change, language disorder and other neuropsychiatric symptoms, which seriously affect the social, professional and life functions of patients, and ultimately lead to death< br / > data show that Alzheimer's disease accounts for 50% to 70% of all types of dementiaThis disease has been paid more and more attention in the worldAccording to statistics, every three seconds, a new dementia patient is diagnosedIn 2018, there are about 50 million people suffering from dementia in the worldBy 2050, the number will increase to 152 million, which means that it will be three times more than nowIt is estimated that the global social dementia related costs in 2018 will be US $1 trillion, which is expected to increase to US $2 trillion by 2030The prevalence of Alzheimer's disease is increasing with the increase of age, which is about 5% in the population over 65 years old and even 20% in the population over 85 years oldTherefore, the prevention and treatment of Alzheimer's disease is very serious< br / > bexarotene (bex) is a new type of retinoic acid drug, which can selectively activate the receptor of retinoic acid x, regulate gene expression, and has significant antitumor activityIn 2000, Beza Rodin oral soft capsules and topical gel were approved by the US Food and Drug Administration (FDA) for the treatment of cutaneous T- cell lymphomaIn recent years, the application of bersalodin in the treatment of lung cancer, breast cancer and ovarian cancer has been widely concernedIn recent years, some scholars began to pay attention to the effect of bersalodine on Alzheimer's disease, which is still in the stage of animal experiment< br / > Lu Hui, Department of Neurology and critical medicine, Huanhu hospital, Tianjin, China, and Zhang Tao, published in Chinese Journal of Neuromedicine in 2014, found that the escape latency of mice in the 3rd, 4th, 5th and 6th day control group, bex high-dose group, bex low-dose group and model group increased gradually, while the stay time in the quadrant of the platform in the 4th day decreased gradually, The number of shocks required for correct response increased gradually, the number of correct responses decreased gradually, and some protein indexes changed accordinglyBetarodine can improve the spatial cognition, learning and memory impairment of Alzheimer's mice, and promote the regeneration of hippocampal nerve< br / > in recent years, foreign researchers have tried to explore the neuroprotective effect of betalodine, a retinoic acid receptor agonist, on the progressive Alzheimer's mice The amyloid precipitates in the nerve cells of 3.5-month-old mice could be removed by two-week drug treatment In 4-month-old and 8-month-old mice, neuron loss was reduced by 44% and 18%, respectively In addition, bersalodine can improve the long-term memory stability and olfaction of mice in fear situation The improvement of these neural activities and functions is related to the significant increase of postsynaptic PSD95 and presynaptic synaptic vesicular protein Moreover, besalodine pretreatment can improve the survival rate of glutamate induced neurotoxic cells in vitro Other benefits include reduced platelet burden, decreased astrocyte proliferation, and inhibition of inflammatory gene expression < br / > there is a long way to go for the influence of drugs on diseases from basic research to clinical application, and the exploration of different effects of drugs needs constant exploration and innovation < br / > References: < br / > M M Mariani, T malm, R lamb, et al Neuroally directed effects of RXR activation in a mouse model of Alzheimer's disease SCI Rep 2017 Feb 16; 7:42270
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