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    Home > Biochemistry News > Biotechnology News > New findings: ActivatorB B and ALK7 form natural barrier stoics against new tumor formation and metastasis

    New findings: ActivatorB B and ALK7 form natural barrier stoics against new tumor formation and metastasis

    • Last Update: 2020-06-03
    • Source: Internet
    • Author: User
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    Activate protein B is an active proteinIt binds and activates tumor growth factor beta (TGF?) A member of the receptor superfamily called ALK7-aWhen activated, ALK7 triggers a domino effect ("signal path") of molecular and biochemical reactions, leading to various changes within the cellimage source: Developmental CellNow a team of researchers at EPFL's Douglas Hanahan laboratory have been the first to find that cancer cells express the activators B and ALK7 to form a "barrier" that not only prevents them from forming new tumors, but also prevents them from metastasisThe project is led by Iacovos PMichael, a former postdoctoral fellow at Hanahan Labsresearchers studied the ALK7 signaling pathway in mice with pancreatic neuroendocrine tumors or breast cancerThey found that when the receptor was activated by the activated protein B, the cancer cells died through a process called apoptosisInstead, stopping the activation of ALK7 allows cancer cells to escape death and successfully transfer to various organs such as the liver, lungs and brainCancer cells evade the activation of the Hormone B/ALK7 "barrier" by lowering the activation hormone B and/or lowering ALK7"This study confirms that apoptosis is an important barrier to tumor development, and that cancer cells escaping apoptosis is a key feature of cancer cells in the process of malignancy and metastasis," saidHanahanin addition, the study also showed that the presence of ALK7 was associated with an increase in the non-recurrence survival (longer recurrence time) of various cancer patients, including breast cancerIt is worth noting that relatively high LEVELS OF ALK7 EXPRESSION WERE ALSO ASSOCIATED WITH LONGER PERIODS OF METASTASIS IN BREAST CANCER PATIENTSThis study describes the role of a until undiscovered protective protein B/ALK7 "barrier" that triggers apoptosis of cells expressing ALK7, so that these cells cannot multiply in specific tissue microenvironmentsIacovos Michael said: "Explaining how cancer cells overcome various 'safety checkpoints' in nature to prevent malignant tumors is an important step in understanding the biology of tumors and the pathogenesis of disease."References: Iacovos PMichael eT alALK7 signaling manifes Ts a homeos TaTic tissue barrier thaT is abroga Ted in h-Samaigenesis and meTasTasDevelopmental Cell 49:1-16, 06 May 2019DOI: 10.1016/j.devcel.2019.04.015original titleDev Cell: Discovering a natural barrier against cancer
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