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    Home > Medical News > Medical World News > New hope for hair loss treatment! Science: Discover miRNA therapy that promotes hair regeneration.

    New hope for hair loss treatment! Science: Discover miRNA therapy that promotes hair regeneration.

    • Last Update: 2020-08-25
    • Source: Internet
    • Author: User
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    Wen . . . Hundreds of millions of people around the world suffer from hair loss.
    genetics, cancer treatment, stress and other factors may be the cause.
    hair loss does not cause serious health problems, but can affect personal image leading to emotional trauma and even depression.
    (antihypertensive potassium channel opener) and non-netrosamine (5 alpha-reductase inhibitor inhibitor of hydrotone) are commonly used hair loss therapy drugs.
    but the two drugs were not originally designed to treat hair loss, but were accidentally discovered.
    because neither is very effective, scientists have been studying the mechanisms of the hair follicle cycle in search of more effective ways to stimulate the hair follicles from the rest of the period to the long-term development.
    July 24
    -- In a paper published in the journal Science Advances, Professor Cheng Ke of North Carolina State University said they identified a miRNA, called miR-218-5p, that promotes hair regeneration and plays a vital role in regulating hair follicle regeneration and could be a promising candidate for future hair loss treatment drug development.
    picture source: Science Advances hair growth depends on the cell health of the hair nipple (dermal papillae, DP) that regulates the hair follicle growth cycle.
    recent studies have shown that hair follicles in bald areas have not disappeared, but have shrunk.
    if DP cells in these areas are replenished, the hair follicles may return to normal, " he said.
    In this study, Cheng's team compared the efficacy of DP cells cultured in two-dimensional (2D) culture with DP cells cultured in 3D (3D) spylical culture using model mice that were widely used in hair-occurring science studies.
    , as expected, the latter works better.
    3D globular DP cells have higher retention and survival rates after transplantation (Figure H, I below) because the porous microstrucular structure of the keratin hydrogel (Figure E, F) maintains DP cell activity and further supports cell adhesion and proliferation.
    addition, the expression of CD133 and beta-catenin in 3D splint DP cells was enhanced compared to DP cells cultured in 2D, while CD133-positive DP cells showed the ability to induce hair in the body.
    : Sciences Advances Focused on hair follicle induction in 3D spyllic DP cells, given the limited therapeutic effects of DP cells cultured in 2D.
    they looked at 20 days of hair growth in the untreated group, the "golden standard" Minodeil-positive control group for hair loss, and the 3D ocular DP cell group.
    results showed that on the 15th day, the hair coverage rate in the Minodir treatment group was 35 per cent, compared with 10 per cent in the untreated group.
    3D splint DP cell group of keratin stent was about 90%.
    The three-dimensional spheel DP cells of the keratin stent perform best because the sphere simulates the microencourse of the hair, and the keratin stent acts as an anchor to keep them where they are needed," said Professor Sciences Advances Chengke.
    In addition, we are interested in how DP cells regulate the hair follicle growth process, and given the importance of side secretion signals in this process, we have studied exosomes, especially exosome miRNAs from this micro-environment.
    "Through Westenblot and immunofluorescence imaging, the researchers confirmed that the exosome secreted by three-dimensional globular DP cells can increase the expression of beta-catenin, thereby promoting hair follicle development."
    , they analyzed the efficacy of miRNA in exosomes isolated from DP cells, and eventually found a key miRNA, miR-218-5p.
    increase in miR-218-5p promotes hair follicle growth, and inhibiting it can cause hair follicles to lose function.
    specifically, miR-218-5p regulates hair follicle development by lowering the WNT signal inhibitor SFRP2, thereby promoting beta-catenin and forming a positive feedback loop.
    miR-218-5p over-expression of exosomes accelerates the long-term occurrence of hair follicles.
    Image source: Sciences Advances May have the following advantages over current hair regenerative therapies: People who are not suitable for invasive surgery can benefit from exosomes through minimally invasive methods such as needleless injections, micro-needle patches, and sprays;
    3D spial DP cell therapy may be an effective way to treat hair loss, but you have to culture, amplification, preserve and inject these cells into bald areas," concluded Professor Science Advances Chengke.
    , miRNA can be applied to small molecule drugs, allowing us to create a cream or emulsion preparation with similar effects and fewer problems.
    future research will focus on the use of this miRNA to promote hair growth.
    " References: 1 s researchers identify microRNA show that the promise for hair regrowth (source: Medical press) 2 s hair Regrowth Therapies May Reside with MicroRNAs (source: GEN) 3 ? Shiqi Hu et al. Dermal exosomes containing miR-218-5p promote hair regeneration by-change. Sci. Adv. (2020) Original title: New Hope for Hair Loss Treatment! Professor Cheng Ke's team, Science, published a paper that found miRNA therapy that promotes hair regeneration.
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