New hope for hair loss treatment! Science: MiRNA therapy found to promote hair regeneration.

Hundreds of millions of people around the world suffer from hair loss.
, cancer treatment, stress and other factors may be the cause.
hair loss does not cause serious health problems, it can affect personal image and lead to emotional trauma and even depression.
(antihypertensive potassium channel opener) and non-nalamines (5 alpha-reductase inhibitors inhibiting dishydrotestosterone) are commonly used hair loss treatments.
but the two drugs were not originally designed to treat hair loss, but were accidentally discovered.
because neither is very effective, scientists have been studying the mechanisms of the hair follicle cycle in search of more effective ways to stimulate hair follicles to grow from the rest of the period.
In a paper published July 24 in the journal Science Advances, a team of professors at North Carolina State University said they have identified a miRNA called miRNAs, called miR-218-5p, that play a crucial role in regulating hair follicle regeneration and could be promising candidates for future hair loss treatments.
image Source: Sciences Advances Hair Growth Depends on the health of the hair nipples (dermal papillae, DP) cells that regulate the hair follicle growth cycle.
recent research shows that the hair follicles in the bald area have not disappeared, but have shrunk.
DP cells in these areas are replenished, the hair follicles may return to normal.
In this study, Cheng's team compared the efficacy of two-dimensional (2D) cultured DP cells with 3D (3D) speral cultured DP cells using model mice that were widely used in hair pathology studies.
as expected, the latter works better.
3D globular DP cells have higher retention and survival rates after transplantation (figure H, I below) because the porous microstruct structure of keratin hydrogels (E, F below) maintains DP cell activity and further supports cell attachment and proliferation.
addition, the expression of CD133 and beta-catenin in three-dimensional speral DP cells was enhanced compared to 2D cultured DP cells, while CD133-positive DP cells showed the ability to induce hair in the body.
Photo Source: Sciences Advances Focuses on hair follicle induction in 3D spter DP cells, given the limited therapeutic effect of DP cells in 2D culture.
they observed 20 days of hair growth in the untreated group, the "gold standard" Minodir-positive control group for treatment of hair loss, and the 3D cytocytocytocyte group.
results showed that on the 15th day, hair coverage was 35 per cent in the Minodir treatment group, compared with 10 per cent in the untreated group.
3D globular DP cell group of keratin stents has hair coverage of about 90%.
Image source: Professor Sciences Advances Cheng Ke said: "Keratin stents perform best in 3D globular DP cells because spheres simulate the microenve environment of hair, and keratin stents act as anchors to keep them where they need to be.
In addition, we are also interested in how DP cells regulate the hair follicle growth process, and given the importance of side secretion signals in this process, we have studied exosomes, especially exosome miRNAs from this micro-environment.
Westernblot and immunofluorescence imaging, the researchers confirmed that 3D globular DP cells secrete exosomes that increase the expression of beta-catenin, thereby promoting hair follicle development.
, they analyzed the effects of miRNA in exosomes isolated from DP cells, and eventually found a key miRNA, miR-218-5p.
miR-218-5p promotes hair follicle growth, and suppressing it causes the hair follicles to lose function.
specifically, miR-218-5p regulates hair follicle development by lowering the WNT signal inhibitor SFRP2, thereby promoting beta-catenin and forming a positive feedback loop.
exosomes that are over-expressed with miR-218-5p accelerate the long-term occurrence of hair follicles.
Photo Source: The discovery may have the following advantages over current hair regeneration therapies: People who are not suitable for invasive surgery can benefit from exosomes given by minimally invasive methods such as needleless injections, micro-needle patches, and sprays;
Photo Source: Science Advances Cheng Ke concludes: "3D cytocytotherapy may be an effective treatment for hair loss, but you have to culture, amplification, preserve and inject these cells into the bald area.
, on the other hand, miRNA can be used in small molecule drugs, which allows us to create a cream or emulsion drug preparation with similar effects and fewer problems.
future research will focus on the use of this miRNA to promote hair growth.
" Reference: 1 s researchers identify microRNA that show show promise for hair regrowth (Source: Medical press) 2 s hair Regrowth Therapies May Reside Micro with RNAs (Source: GEN) 3 s shiqi Hu et al. Dermal exosomes containing miR-218-5p promote hair regeneration by normaling beta-catenin signaling. Sci. Adv. (2020) Original title: New Hope for Hair Loss Treatment! Professor Cheng Ke's team, Science Sub-Publish, found miRNA therapy that promotes hair regeneration.