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The joint team of researcher Gao Xiaoling from the Department of Pharmacology and Chemical Biology, Shanghai Jiaotong University School of Basic Medicine and Professor Chen Hongzhuan from Shanghai University of Traditional Chinese Medicine has constructed a multifunctional lipid for the early pathological events of cerebrovascular dysfunction in Alzheimer’s disease (AD) The protein biomimetic nanostructure RAP-RL remodels the neurovascular unit (NVU), which can effectively reverse the spatial learning and memory deficits of AD model mice, and provides new targets and new ideas for Alzheimer's disease intervention.
The neurovascular unit is composed of neurons-glial cells-blood vessels, and is an important structure to maintain the stability of the brain microenvironment.
The research aimed at different links in the pathogenesis of neurovascular unit disease and Alzheimer's disease, and developed a multifunctional integrated lipoprotein biomimetic nanostructure RAP-RL, which can identify the high expression on brain vascular endothelial cells injured by Alzheimer's disease.
Experimental results show that intravenous injection of RAP-RL can effectively damage brain microvasculature, improve cerebral blood flow, and significantly reverse the spatial learning and memory impairment of Alzheimer's disease transgenic APP/PS1 mice.