New methods of purification of cancer CAR-T immunotherapy preparations have been found in Australia

Xinhua News Agency, Canberra, October 26 (Reporter Yue Dongxing Baixu) The University of South Australia recently issued a communique that the university researchers in collaboration with a biotherm company, developed a new method based on microflow technology to purification of cancer CAR-T immunotherapy preparations, can reduce treatment costs and side effects.
CAR-T immunotherapy for cancer is the extraction of the cancer patient's own immune T cells and bioengineering them to identify and attack specific cancer cells, which are then returned to the patient for treatment. This is a new cancer therapy that has been highly expected by the research and development community in recent years.
Mona Elsmary, who was involved in the study, said CAR-T immunotherapy has yielded positive results in the treatment of blood cancers such as leukemia, and some teams are studying its use to treat solid tumors, but the potential for the treatment has not yet been fully realized.
she said, in addition to the high cost of the problem affecting the application of this treatment, there are CAR-T preparations in the impurities are more difficult to remove, these impurities include dead cells, metformin and other antifreeze. Dead cells can cause serious side effects on patients, and antifreeze can trigger allergic reactions and toxic side effects in some patients.
The new method, developed, removes more than 70 percent of dead cells from CAR-T preparations in 30 minutes, as well as more than 90 percent of metformin, with no adverse effects on the quality and function of immune cells, the press release said. The results can benefit patients by reducing the cost and side effects of CAR-T immunotherapy.