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    Home > Medical News > Medical Science News > New nanoparticles can improve the treatment effect of malignant brain tumor

    New nanoparticles can improve the treatment effect of malignant brain tumor

    • Last Update: 2020-12-18
    • Source: Internet
    • Author: User
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    U.S. researchers have designed a new type of nanoparticle that can transport both drugs to the tumor site of the brain at the same time, enhancing the effectiveness of treatment for a high-mortality brain tumor, polymorphic glioblastoma, which has been successful in animal experiments.
    polymorphic glioblastoma is a common malignant brain tumor that is difficult to treat and has a high mortality rate. Direct injection of drugs is difficult to reach the brain and tumor cells through the blood-brain barrier to quickly develop resistance to a single drug, is the treatment of the disease's two major difficulties.
    researchers at the Massachusetts Institute of Technology reported on
    that they coat lipid nanoparticles with transirin, allowing particles to pass smoothly through the blood-brain barrier and accurately reach tumor sites while avoiding normal cells.
    lipid body is a hollow artificial spball particle, the shell is a lipid double molecule layer. The researchers installed the chemotherapy drug tymoamine inside the liposome, which destroys the DNA of tumor cells (deoxyrucleic acid), and shelled an experimental drug called "JQ-1" to stop tumor cells from repairing DNA damage. Together, they reduce drug resistance.
    the lipids, which were coated with trans ferrin, worked better than direct injection drugs, and the brain tumors in the mice shrunk more and survived more. In addition, the new method also avoids some adverse reactions caused by direct injection of the drug.
    could also be used to transport other cancer drugs, the researchers said. The presence of a blood-brain barrier prevents many drugs from being used in brain tumors, and new technologies will change that and expand the range of options. (Source: Xinhua News Agency)
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