New nanotechnology fights aggressive cancer

University of Arizona health science researchers recently completed a study that has the potential to use nanotechnology to provide chemotherapy to make it more effective against aggressive tumors, thereby improving the treatment of rectal cancer and melanoma

"I have always been interested in using innate immunity to fight cancer," said Jianqin Lu, Ph.

Immunotherapy helps strengthen the immune system's ability to fight cancer cells

ICB therapy is effective for certain types of cancer, but not all patients

Recent research has focused on enhancing the effectiveness of ICB therapy by combining ICB with chemotherapeutic drugs such as camptothecin

Dr.

"In order to provide more effective ICB treatments, we have developed a nanotherapy platform that can convert tumors from'immune cold' to'immune hot'," said Dr.

The research team attached camptothecin to sphingomyelin, a natural lipid found on the surface of cells

Dr.

The researchers pointed out that their nanotechnology platform can provide a range of cancer therapies

Dr.

Nature Nanotechnology.

Immunogenic camptothesome nanovesicles comprising sphingomyelin-derived camptothecin bilayers for safe and synergistic cancer immunochemotherapy