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The study, "Non-canonical projections to the hippocampal CA3 regulate spatial learning and memory by modulating the feedforward hippocampal trisynaptic pathway," is published today in the journal PLOS Biology
.
The hippocampus is not a single brain region
.
The temporal-septal axis, where the trisynaptic pathway is located, separates the dorsal hippocampus from the ventral region.
"Our findings extend knowledge about hippocampal connectivity and its relationship to learning and memory processes, and provide a circuit basis for exploring these new functional roles
.
" Director of the Center for Neural Circuit Mapping, Chancellor's Fellow, Anatomy, UCI School of Medicine said Xiangmin Xu, Ph.
Building on their earlier work, Xu and his team used a variety of viral tracers, including monosynaptic rabies retrograde tracing and herpes (H129)-based anterograde tracing to establish new hippocampal CA1 to CA3 projections
.
Robust mapping results show that the CA1 to CA3 input opposes the trisynaptic pathway and runs in the temporal lobe-to-septal direction
"The advent of viral gene mapping technology has enhanced our ability to determine the complexity of the details of brain circuits," Xu said
.
"Our research is enabled by new viral genetic tools developed by CNCM researchers at UCI
Other members of the research team include: UCI anatomy and neurobiology graduate student Xiaoxiao Lin, first author of the paper; biomedical engineering undergraduate Michelle Amaraji; Crisylle Blanton and neurobiology undergraduate researcher Brenda Avila
.
Other key contributors to the study include Douglas A.
This work was supported by NIH Brain Initiative grants NS078434 and MH120020; and NIH R35 grant GM127102
Journal Reference :
Xiaoxiao Lin, Michelle Amalraj, Crisylle Blanton, Brenda Avila, Todd C.
