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A new study led by engineering researchers from the Twin Cities of the University of Minnesota shows that the firmness of protein fibers in tissues, such as collagen, is a key component that controls cell movement
The research was published in the Proceedings of the National Academy of Sciences (PNAS), a peer-reviewed, multidisciplinary, high-impact scientific journal
The directional movement of cells, which scientists call "cell contact guidance", refers to a phenomenon in which the direction of cells is affected by the arrangement of fibers in soft tissues
Robert Tranquilo said: "It's like someone throwing you into a swimming pool full of water, asking you to swim a few laps, and then turn off the lights
There are many reasons why cells need to move
"Even though we use many processes of cell contact, engineers in my laboratory instructed tissues to mimic heart valves and blood vessels, triggering a consistent signal of cell movement fiber network has been unclear for all of us all these years," said quietly, an outstanding Mike Professor of Knight University
In this new research aimed at understanding contact guidance and improving tissue engineering, Tranquillo’s team worked with researchers at the University of California, Irvine and the University of California to test fibers in two neatly arranged fibrous gels.
Tranquilo said: "Using a set of special tools that we couldn't use before, we were able to test skin cells that we thought were the'workhorses' of the development engineering organization
Tranquillo said this is the first time anyone has been able to prove a major aspect of the contact guidance theory, which was first proposed by Graham Dunn at King's College London in 1982
The next step is to study the porosity and adhesion of fibers, to see if they have an effect on cell movement, and to study other types of cells
"This is just the first step in truly understanding how cells move," Tranquilo added
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"Cell contact guidance via sensing anisotropy of network mechanical resistance," visit the <a href="https://z.