New progress has been made in the research on the nasal spray vaccine of the new coronavirus

Recently, Zheng Aihua's research group, Institute of Zoology, Chinese Academy of Sciences, together with Qin Chengfeng's research group, Institute of Microbial Epidemiology, Academy of Military Medical Sciences, and Dr.

With the approval of several inactivated vaccines, mRNA vaccines, subunit vaccines and adenoviral vector vaccines, countries are working to increase vaccination rates

By replacing the G protein of VSV with the S protein of the new coronavirus, Zheng Aihua's research group constructed a replicable rVSV-SARS-CoV-2 vector vaccine and applied for a patent in March 2020

The SARS coronavirus is related to the new coronavirus.

These results lay the foundation for the development of rVSV-SARS-CoV/2-RBD as an effective vaccine candidate for SARS-CoV-2

Li Hongyue and Zhang Yuhang, graduate students of the Institute of Zoology, Chinese Academy of Sciences, Li Dong from Shenzhen Kangtai Biotechnology Co.

Paper link: https:// .

Figure 1: Schematic diagram of rVSV-SARS-CoV/2-RBD vaccine design

Figure 2: Protective effects of rVSV-SARS-CoV-2 and rVSV-SARS-CoV/2-RBD on hACE2 mice