New progress has been made in the study of the molecular mechanism of single-footed kineter signal transduction

one-footed gold esters are a new type of plant hormone, which play an important role in the construction of plant strains and can inhibit the elongation of plant side buds as long-distance signaling molecules, thus inhibiting the production of branches, which is of great scientific significance and application value to the study of their signaling pathways. Li Jiayang Research Group of the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences and its partners have been engaged in the study of the molecular mechanism of rice strain formation for a long time, and have made a systematic and in-depth analysis of the synthesis and signal transductivity of ideal strain type and one-footed gold esters. Previously, they cloned the ideal strain of rice gene IPA1 (Ideal Plant Architecture 1), proving that it encodes a transcription factor containing SBP-box domain, regulates multiple growth and development processes, has an important impact on rice yield (Jiao et al., Nat Genet, 2010), and has a significant effect on yield increase in breeding. At the same time, they identified the key negative regulatory factor Dwarf 53 (D53) in the one-footed kineter signal path, and analyzed the "de-inhibition activation" mechanism for single-footed kineter signal transducting (Jiang et al., Nature, 2013).
's latest research shows that IPA1 functionally missing mutants exhibit esoteric patterns with increased number of splits, and are insensitive to the synthetic similar rac-GR24 applied to external sources, and that the D53 protein interacts directly with the IPA1 protein to inhibit transcriptional activation activity of IPA1, thereby inhibiting downstream gene expression. In addition, IPA1 was found to bind directly to the promoter of D53 and activate the expression of the D53 gene, thus forming negative feedback regulation. The results reveal that IPA1 is a long-sought transcription factor downstream of D53, which participates in the signaling pathway of one-footed gold esters and is directly regulated by D53. The findings were published online August 15, 2017 in cell Research
. Song Xiaoguang, a postdoctoral fellow in the Lijiayang Research Group, Lu Zhifu, a graduate doctoral student, and Yu Wei, an associate researcher, are co-authors of the paper, and Li Jiayang is the author of the communication. The collaborators include Wang Yonghong, a researcher at the Institute of Genetic Development of the Chinese Academy of Sciences, Liu Chunming, a researcher at the Crop Science Institute of the Chinese Academy of Agricultural Sciences, and Professor Li Hongqing of South China Normal University. The research has been funded by the National Key Research and Development Program, the National Natural Science Foundation of China project and the Pilot A project of the Chinese Academy of Sciences. (Source: Science.com)