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    Home > Biochemistry News > Biotechnology News > New research in the sub-journal of Nature reveals the regulatory mechanism of hematopoietic stem cells entering the bone marrow for the first time

    New research in the sub-journal of Nature reveals the regulatory mechanism of hematopoietic stem cells entering the bone marrow for the first time

    • Last Update: 2022-05-22
    • Source: Internet
    • Author: User
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    Hematopoietic Stem Cells (HSCs) are like "seeds" of blood, capable of producing almost all types of blood cells through proliferation and differentiation
    .
    Therefore, hematopoietic stem cell transplantation after radiotherapy and chemotherapy has been widely used in the treatment of various malignant hematological diseases

    .

    In adult mammals, hematopoietic stem cells mainly exist in the bone marrow, and their maintenance, quiescence and proliferation are regulated by the bone marrow microenvironment
    .
    So, how did this "seed" take root in the "soil" of the bone marrow? The research on the mechanism of hematopoietic stem cell engraftment into bone marrow will help to improve the efficiency of hematopoietic stem cell transplantation

    .

    Recently, a new study completed by the Max Planck Institute of Germany, the School of Medicine of South China University of Technology, and the Guangzhou Institute of Biomedicine and Health of the Chinese Academy of Sciences found that during the development of hematopoietic stem cells, arterial blood vessels regulate hematopoietic stem cells for the first time into the embryo.
    stage bone marrow

    .
    The research results were published in the journal Nature Communications, a division of Nature

    .

    The researchers point out that the interaction between adult animal hematopoietic stem cells and the bone marrow microenvironment has been well studied, but little is known about how the embryonic bone marrow microenvironment regulates the behavior of hematopoietic stem cells
    .
    Therefore, they first compared the bone marrow microenvironment in adulthood and embryonic life by single-cell sequencing

    .
    The analysis found that the cellular composition and molecular interactions of hematopoietic stem cells and the bone marrow microenvironment differ greatly between embryonic and adulthood

    .
    For example, the adult-important microenvironment Lepr+ cells hardly exist during the embryonic period and naturally do not function in the microenvironment

    .

    Using genetically manipulated mice, the researchers found that, unlike in adulthood, bone nerves do not function as a hematopoietic stem cell microenvironment during embryonic development
    .
    Lack of bony nerves did not significantly affect the number of hematopoietic stem and progenitor cells (HSPCs) in the bone marrow

    .

    ▲The huge difference between hematopoietic stem cells and bone marrow microenvironment between embryonic and adulthood (Image source: Reference [1])

    The experimental results revealed that the bone artery is the key microenvironmental cell in the embryonic stage
    .
    At 16.
    5 days of mouse embryonic development, the vast majority of hematopoietic stem/progenitor cells were located next to arterial vessels

    .
    At this time, the bone marrow arteries can release the signaling molecule Wnt2, and the arterial-derived Wnt signaling affects the expansion of hematopoietic stem/progenitor cells

    .

    Using recombinant protein Wnt2 to treat hematopoietic stem/progenitor cells in vitro can promote the proliferation of hematopoietic stem/progenitor cells and enhance the ability of hematopoietic stem/progenitor cells to form clones in vitro
    .
    These results suggest that the embryonic-stage-specific microenvironmental factor Wnt2 can improve the efficiency of early transplantation

    .

    ▲Hematopoietic stem cells gather next to arterial blood vessels during embryonic stage (Image source: Reference [1])

    Note: The original text has been deleted

    References:

    [1] Yang Liu et al.
    , (2022) A specialized bone marrow microenvironment for fetal haematopoiesis.
    Nature Communications.
    Doi: https://doi.
    org/10.
    1038/s41467-022-28775-x

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