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Retinal pigment epithelium is a layer of pigment cells in the retina that resembles barriers and regulators in the eye that help maintain normal vision; abnormal function of retinal pigment epithelocytes can lead to eye disorders, including retinal macular degeneration, and can even induce blindness, which affects the health of about 200 million people worldwide.
To restore the function of retinal pigment epithelial cells, the researchers extracted retinal stem cells from the eyes of donated adult carcasses to match the compatibility of the commons and serve as a circulating source for human retinal pigment epithelial cells;
researchers found that retinal pigment epithelial cell plaques transplanted into macular tissue or the central region of the retina remain stable and intact in the body for at least three months without serious side effects on the recipient, such as immune attacks or light sensitivity. In addition, stem cell-derived retinal pigment epithelocells can take over at least part of the function of the original retinal pigment epithelocyte cells and support the function of endotopic photorescers, thus helping to absorb light and moisture and other functions.
researcher Dr Timothy Blenkinsop said retinal pigment epithellal cells derived from human cerenial feeds could partially replace the function of retinal macular regions in the eyes of non-human primates; The function of the host is therefore likely to be a very promising source of saving patients with retinal disease, and the results of this paper show that transplantation using retinal pigment epithelial cells from adult receptors is very safe, which also strengthens the rationale for human clinical trials to treat retinal disease.
Finally, the researchers point out that transplants from retinal pigment epithellal stem cells in the eyes of adult corpses to replace functionally impaired retinal pigment epithellocy cells, or as a potential new treatment for effective treatment of retinal macular degeneration, more in-depth research is needed later to clarify whether retinal pigment epithellin stem cells derived from human cervisia can restore vision in human patients and diseased non-human primate model eyes.
original source: Zengping Liu, Bhav Harshad Parikh, Queenie Shu Woon Tan, et al. Surgical Transplantation of Human RPE Stem Cell-Derived RPE Monolayers into Non-Human Primates with Immunosuppression,Stem Cell Reports (2021). doi:10.1016/j.stemcr.2020.12.007