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Pediatric high-grade gliomas (pHGGs, Pediatric high-grade gliomas) include glioblastoma multiforme (GBM) and diffuse intrinsic pontine glioma (DIPG, diffuse intrinsic pontine glioma), all of which are pathological Brain tumors; even if the patient is treated, the survival rate is still very low, which makes pHGGs the number one cause of death from cancer in children.
In each cell, the two-meter-long DNA needs to be properly folded and organized so that it can be packed into the nucleus, which is usually only a few microns; in many cases, the DNA will form a ring, which will usually be in the entire genome.
Chromatin ring affects bladder cancer
In a research report published in Genome Biology, researchers found that the 3D structure of chromatin affects the progression of bladder cancer.
In the article, the researchers analyzed the characteristics of none of the cancer subtypes in samples from multiple patients, and analyzed their epigenetic characteristics and chromatin loop characteristics.
Researcher Yue said that we may be able to manipulate NPAS2 and other key regulators so that we can induce the switch of cancer subtypes, which has a profound impact on the prognosis of cancer patients and the effect of treatment
Abnormal ring structure may promote brain cancer progression
In another research report published in the international journal Science Advances, researchers found through research that abnormal chromatin loops may be directly related to DIPG, which is a fatal childhood brain cancer; most of the time, chromatin All are condensed in the nucleus.
In normal cells, there is a baseline amount of these interactions or chromatin loops, but when testing DIPG cells, the researchers found more looping events.
In summary, the results of the above two studies indicate that 3D gene changes may play a key role in the blueprint of pHGG epigenetics and the promotion of tumorigenesis
Original source:
Iyyanki, T.
Juan Wang, Tina Yi-Ting Huang, Ye Hou, et al.
DOI: 10.
