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Mycobacterium tuberculosis (Mtb) is the leading cause of death worldwide, causing more than 1.
Researchers at Purdue University and Houston Methodist University combined autophagy-mediated antigen presentation to create this new tuberculosis vaccine formulation, which initiates an enhanced T cell response
Mittal said: "Our vaccination method is equally effective without or with prior BCG vaccination
Jagannath said: "This is crucial because most people in countries where tuberculosis is endemic have already been vaccinated with BCG
Mittal's laboratory researches vaccine delivery platforms, and Jagannath's laboratory uses the nasal delivery route in the development of tuberculosis vaccines
Mittal said: "The great thing about this TB research is that it can be transformed into other infectious diseases, and possibly cancer immunotherapy
The next step in the vaccine formulation is to study the efficacy of the vaccine in a non-human primate model
Arshad Khan, Ekramy E.