The cartoon is produced by the China Science News
The cartoon is produced by the China Science News At 23:00 on July 27, 2021, Beijing time, Cell Reports published online research on mammalian circular RNA by Dr.
Cell Reports The study gave a series of evidence that most of the circular RNA originates from splicing errors, and estimated that more than 97% of the circular RNA is useless or even harmful
Circular RNA is a closed circular RNA structure formed by splicing machines connecting the 3 ends of exons to the 5 ends of upstream exons through back splicing (as shown in the figure below)
In response to the current “adaptive” view in the field of circular RNA research—circular RNA generally has functions, the author puts forward a “molecular error” hypothesis that is opposed to it.
In order to estimate the proportion of harmful reverse splicing, the author assumes that reverse splicing in highly spliced genes is left over after natural selection, so it is mainly non-harmful reverse splicing ( ND ); and the reverse splicing of genes currently observed There are both harmful and non-harmful reverse splicing ( T ) in the
ND T Odel = (T-ND)/T=1-ND/T This study shows that most of circular RNAs come from splicing errors, so most of them should be junk RNA
This study is consistent with the author's previous series of studies (including gene variable transcription initiation and termination, RNA synthesis and post-transcriptional modification, variable translation initiation and termination, translation extension and post-translational modification), indicating that gene transcription Unlike translation prone to errors, the molecular processes in cells are not as perfect as most people think
Related paper information: https://doi.
https://doi.
org/10.
1016/j.
celrep.
2021.
109439 https://doi.
org/10.
1016/j.
celrep.
2021.
109439
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