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Original title: New study: Coffee bean shell helps reduce inflammation and insulin resistance
Coffee bean shell is a by-product of coffee production and is often used as fertilizer, etc. Extracts from coffee bean shells can slow obesity-related inflammation in laboratory mice and increase insulin sensitivity, a US study has found.
A team led by researchers at the University of Illinois in the United States extracted two phenolic substances, primary teac acid and pentagonolic acid, from the coffee bean shell and the "silver skin" that had fallen off after roasting, and used them to treat fat cells in mice, observing changes in macrophages and fat cells in mice and related hormones, as well as reactions to inflammatory pathogens.
previous studies have found chronic inflammation of abdominal adipose tissue in severely overweight people, which is often thought to be a factor in changes in insulin levels, leading to type 2 diabetes, and even increases the risk of cancer in obese people.
The new study, published in the British journal Food and Chemical Toxicology, showed that when obesity-related inflammation occurs, macrophages interact with fat cells, mitochondrials in fat cells decrease, fat burning ability decreases, and oxidative stress levels increase, disrupting glucose absorption. The metabolic rate slows down, while the phenolic substances extracted from the coffee bean shell can block the effects of macrophages on fat cells, keeping fat burning, stimulating fat breakdown, and stimulating the sensitivity of insulin pathogenes, promoting glucose intake and utilization, and restoring normal metabolism.
could lead to new treatments for type 2 diabetes and cardiovascular disease, as well as potential business opportunities for coffee bean shells, the researchers said.